Objectives: To assess the implementation of home blood pressure measurement (HBPM) by French general practitioners (GPs) in current practice in 2009 and to assess the evolution of practices between 2004 and 2009; the perceived benefits and limitations of the method; and the adherence to methodological European [European Society of Hypertension (ESH) 2007] or French [La Haute Autorité de Santé (HAS) 2005] recommendations.
Method: Two phone surveys on a representative random sample of French GPs in 2004 and then in 2009.
Results: Five hundred and forty and 801 GPs were contacted in 2004 and 2009, respectively, in which 511 and 500 participated, including the same 214 in both surveys. The proportion of HBPM users increased between 2004 (70%) and 2009 (92%) (P < 0.0001). The majority still remained occasional users (71%), whereas a minority (21%) used this method nearly systematically in 2009. In 2009, both users and nonusers highlighted the lack of reliability of devices (19 and 47%) and lack of patient reliability (27 and 24%) and patient anxiety (47 and 29%). The expected benefit was primarily the detection of white-coat effect (70%), therapeutic adaptation (36%), diagnostic aid (25%), and better compliance with treatment (14%). Masked hypertension detection (2%) and prognostic interest (0.7%) were marginal. The GPs declared rarely adopting ESH methodology (3% of users), but more often HAS methodology (33%). Adherence to the complete methodology was rare (absolute adherence <1%), but more often 'minimal' (three morning and evening measurements, at least 3 days with an upper arm cuff: 17%). Contraindications of HBPM use were not known.
Conclusion: Despite greater use of HBPM after enactment of the recommendations, the methodology is not strictly implemented, making its diagnostic and prognostic value uncertain.
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http://dx.doi.org/10.1097/HJH.0b013e32834b7efb | DOI Listing |
BMC Med
January 2025
Department of Gynaecology and Obstetrics, Women and Children's Hospital of Chongqing Medical University (Chongqing Health Center for Women and Children), Chongqing, China.
Background: Prospective trial evidence is lacking regarding the application of enhanced recovery after surgery (ERAS) in transvaginal pelvic floor reconstruction surgery among older patients. Our study aimed to investigate whether implementing the ERAS protocol could enhance post-operative recovery in this patient population.
Methods: Older patients undergoing elective transvaginal pelvic floor reconstruction surgery were randomly assigned to either the ERAS group or the conventional group.
J Immunol Methods
January 2025
Research & Development Department, Cellular Technology Limited, Shaker Heights, OH 44122, USA. Electronic address:
Owing to their ability to reliably detect even very rare antigen-specific B cells in cellular isolates such as peripheral blood mononuclear cells (PBMC), and doing so robustly in a high throughput-compatible manner, B cell ELISPOT/FluoroSpot (collectively "B cell ImmunoSpot") tests have become increasingly attractive for immune monitoring in regulated settings. Presently, there are no guidelines for the qualification and validation of B cell ImmunoSpot assay results. Here, we propose such guidelines, building on the experience acquired from T cell ImmunoSpot testing in an environment adhering to the requirements of regulatory bodies yet taking the unique features of B cell assays into account.
View Article and Find Full Text PDFEur Arch Otorhinolaryngol
January 2025
Department of Otolaryngology-Head and Neck Surgery, IRCCS Regina Elena National Cancer Institute, Istituti Fisioterapici Ospitalieri (IFO), Via Elio Chianesi 53, 00144, Rome, Italy.
Objectives: we evaluated the hypothesis that level of ctHPVDNA on the first postoperative day (POD-1); and at 15 days (POD-15) could be associated with the need for adjuvant therapy and the presence of recurrence.
Materials And Methods: this is a prospective observational study on biomarkers, focusing on the longitudinal monitoring of ctHPVDNA in a cohort of HPV-OPSCC patients undergoing TORS. Blood samples were collected according to the following schema: (1) pretreatment; (2) on first postoperative day (POD 1); and (3) at 15 days (POD 15).
Bioinformatics
January 2025
Section of Bioinformatics, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, W12 0NN, United Kingdom.
Unlabelled: Metabolomics extensively utilizes Nuclear Magnetic Resonance (NMR) spectroscopy due to its excellent reproducibility and high throughput. Both one-dimensional (1D) and two-dimensional (2D) NMR spectra provide crucial information for metabolite annotation and quantification, yet present complex overlapping patterns which may require sophisticated machine learning algorithms to decipher. Unfortunately, the limited availability of labeled spectra can hamper application of machine learning, especially deep learning algorithms which require large amounts of labelled data.
View Article and Find Full Text PDFCancer Causes Control
January 2025
Huntsman Cancer Institute, Salt Lake City, UT, USA.
Background: Non-Hodgkin lymphoma (NHL) is the seventh most common cancer among Asian, Native Hawaiian and Pacific Islanders (ANHPIs), yet the risk of death in specific ANHPI subgroups in the US is unknown.
Methods: We used Surveillance, Epidemiology, and End Results data to investigate relative survival and the risk of death among NHL patients in ANHPI subgroups. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals (CI), comparing ANHPI subgroups to non-Hispanic White (NHW) NHL patients for all-cause death and NHL-specific death.
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