Amygdala lesions selectively impair familiarity in recognition memory.

Nat Neurosci

Center for Memory and Brain, Boston University, Boston, Massachusetts, USA.

Published: September 2011

A major controversy in the study of memory concerns whether there are distinct medial temporal lobe (MTL) substrates of recollection and familiarity. Studies using receiver operating characteristics analyses of recognition memory indicate that the hippocampus is essential for recollection, but not for familiarity. We found the converse pattern in the amygdala, wherein damage impaired familiarity while sparing recollection. Combined with previous findings, these results dissociate recollection and familiarity by selective MTL damage.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203336PMC
http://dx.doi.org/10.1038/nn.2919DOI Listing

Publication Analysis

Top Keywords

recollection familiarity
12
recognition memory
8
familiarity
5
amygdala lesions
4
lesions selectively
4
selectively impair
4
impair familiarity
4
familiarity recognition
4
memory major
4
major controversy
4

Similar Publications

The viewpoint that unitization provides a possibility of increasing the contribution of familiarity to associative memory has been widely accepted, but its effects on associative memory and recollection remain controversial. The current study aims to explain these mixed results by considering a potential moderator: changes in the level of unitization from encoding to retrieval phases. During the encoding phase, participants learned the related and unrelated picture pairs (i.

View Article and Find Full Text PDF

Episodic memory is accounted for with two processes: "familiarity" when generally recognizing an item and "recollection" when retrieving the full contextual details bound with the item. We tested a combination of item recognition confidence and source memory, focusing upon three conditions: "item-only hits with source unknown" ('item familiarity'), "low-confidence hits with correct source memory" ('context familiarity'), and "high-confidence hits with correct source memory" ('recollection'). Behaviorally, context familiarity was slower than the others during item recognition, but faster during source memory.

View Article and Find Full Text PDF

A normative database of Swahili-Chinese paired associates.

Behav Res Methods

January 2025

Institute of Developmental Psychology, Faculty of Psychology, Beijing Normal University, No.19 Xinjiekouwai Street, Haidian District, Beijing, 100875, China.

Over the past few decades, Swahili-English and Lithuanian-English word pair databases have been extensively utilized in research on learning and memory. However, these normative databases are specifically designed for generating study stimuli in learning and memory research involving native (or fluent) English speakers. Consequently, they are not suitable for investigations that encompass populations whose first language is not English, such as Chinese individuals.

View Article and Find Full Text PDF

The precise and fleeting moment of rich recollection triggered by an environmental cue is difficult to reproduce in the lab. However, epilepsy patients can experience sudden reminiscences after intracranial electrical brain stimulation (EBS). In these cases, the transient brain state related to the activation of the engram and its conscious perception can be recorded using intracerebral EEG (iEEG).

View Article and Find Full Text PDF

According to the predictive processing framework, our brain constantly generates predictions based on past experiences and compares these predictions with incoming sensory information. When an event contradicts these predictions, it results in a prediction error (PE), which has been shown to enhance subsequent memory. However, the neural mechanisms underlying the influence of PEs on subsequent memory remain unclear.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!