Purpose Of Review: The review highlights the recent advances in the pathogenesis, diagnosis and treatment of AIDS-related primary CNS lymphoma (AIDS-PCNSL).
Recent Findings: The incidence of AIDS-PCNSL has decreased in the era of highly active antiretroviral therapy (HAART). The prognosis has improved and this most probably in relation both with the HAART-induced immunologic status recovery and subsequently the possibility to use more aggressive treatment strategies. Immunomodulatory effect of HAART seems also to have an indirect antitumor activity on the disease.
Summary: The treatment strategy for AIDS-PCNSL in the HAART era tends to become similar to that of the immunocompetent population. In the absence of randomized trials devoted to AIDS-PCNSL, most current national comprehensive cancer network guidelines recommend the use of high-dose methotrexate-based chemotherapy combined or not with whole-brain radiotherapy as initial treatment in addition to HAART. The objective for the future would be that prognosis of AIDS-PCNSL catch up with that of the immunocompetent patients with special attention to systemic and neurocognitive tolerance of the treatments.
Context: Micronutrient deficiencies are common and frequently co-occurring among people living with HIV (PLHIV) globally, with consequences for their health and clinical outcomes. Previous reviews of the influence of micronutrient supplementation on HIV outcomes were conducted in the pre-highly active antiretroviral therapy (pre-HAART) era or included both HAART-naive and HAART-experienced individuals; thus, the evidence in the context of HAART is inconclusive.
Objective: A systematic review and meta-analysis was conducted to evaluate the effect of micronutrient supplementation on important clinical outcomes among PLHIV on HAART.
The study investigates oral health issues among children living with HIV in Bafoussam, Cameroon, highlighting the continued public health challenge posed by HIV even with effective treatment.
It involved a survey of 163 children, showing high rates of viral suppression; however, many experienced oral health problems such as gingivitis and cavities, with poor dental consultation rates.
The findings suggest that while HAART is effective, better oral hygiene practices and early treatment initiation are essential to mitigate these health issues.
- The study compared comorbidity burdens between long-term HIV survivors diagnosed before 1996 and those diagnosed after 2006, focusing on age-matched groups.
- It found that long-term survivors had more comorbidities on average (2.6) than the modern ART group (1.9), with metabolic and cardiovascular issues being the most common.
- The analysis indicated that older age and longer antiretroviral therapy duration were linked to a higher number of comorbidities, suggesting a greater health impact for long-term survivors.
Purpose: To characterize patients with cytomegalovirus (CMV) retinitis and identify risk factors for retinal detachment (RD) and mortality in this Taiwanese patient population.
Methods: This retrospective study included patients diagnosed with CMV retinitis between 2007 and 2019. The diagnosis was confirmed through aqueous polymerase chain reaction (PCR).
Objective: This study examined the prevalence, severity and risk factors of anaemia among adult people living with HIV attending an antiretroviral therapy centre in Woreta Primary Hospital, Woreta town, Ethiopia.
