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The droplet dynamics of asymmetrical impingement on moving ridged surface.
J Colloid Interface Sci
January 2025
School of Energy and Power Engineering, University of Shanghai for Science and Technology, Shanghai 200093 China. Electronic address:
Hypothesis: The depth of research into the mechanism of droplet impacting structured surfaces dictates the efficacy of their applications. The impact stress generated when a droplet impacts a surface is a pivotal factor influencing the efficiency of surface applications, ultimately determining the extent of surface wear. Despite the systematic examination of impact force, there remains a scarcity of research on impact stress and its mitigation strategies.
View Article and Find Full Text PDFCalcium signaling hypothesis: A non-negligible pathogenesis in Alzheimer's disease.
J Adv Res
January 2025
Tianjiu Research and Development Center for Exercise Nutrition and Foods, Hubei Key Laboratory of Exercise Training and Monitoring, College of Sports Medicine, Wuhan Sports University, Wuhan 430079, China. Electronic address:
Background: Alzheimer's disease (AD) presents a significant challenge to global healthcare systems, with an exacerbation by an aging population. Although the plethora of hypotheses are proposed to elucidate the underlying mechanisms of AD, from amyloid-beta (Aβ) accumulation and Tau protein aggregation to neuroinflammation, a comprehensive understanding of its pathogenesis remains elusive. Recent research has highlighted the critical role of calcium (Ca) signaling pathway in the progression of AD, indicating a complex interplay between Ca dysregulation and various pathological processes.
View Article and Find Full Text PDFN-methyl-D-aspartate Receptors and Depression: Linking Psychopharmacology, Pathology and Physiology in a Unifying Hypothesis for the Epigenetic Code of Neural Plasticity.
Pharmaceuticals (Basel)
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Relmada Therapeutics, Inc., Coral Gables, FL 33134, USA.
Uncompetitive NMDAR (N-methyl-D-aspartate receptor) antagonists restore impaired neural plasticity, reverse depressive-like behavior in animal models, and relieve major depressive disorder (MDD) in humans. This review integrates recent findings from in silico, in vitro, in vivo, and human studies of uncompetitive NMDAR antagonists into the extensive body of knowledge on NMDARs and neural plasticity. Uncompetitive NMDAR antagonists are activity-dependent channel blockers that preferentially target hyperactive GluN2D subtypes because these subtypes are most sensitive to activation by low concentrations of extracellular glutamate and are more likely activated by certain pathological agonists and allosteric modulators.
View Article and Find Full Text PDFThe Quantum Memory Matrix: A Unified Framework for the Black Hole Information Paradox.
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Terra Quantum AG, Kornhausstrasse 25, 9000 St. Gallen, Switzerland.
We present the Quantum Memory Matrix (QMM) hypothesis, which addresses the longstanding Black Hole Information Paradox rooted in the apparent conflict between Quantum Mechanics (QM) and General Relativity (GR). This paradox raises the question of how information is preserved during black hole formation and evaporation, given that Hawking radiation appears to result in information loss, challenging unitarity in quantum mechanics. The QMM hypothesis proposes that space-time itself acts as a dynamic quantum information reservoir, with quantum imprints encoding information about quantum states and interactions directly into the fabric of space-time at the Planck scale.
View Article and Find Full Text PDFA unified model for droplet receding contact angles on hydrophobic pillar, pore, and hollowed pillar arrays.
J Colloid Interface Sci
December 2024
Department of Mechanical Engineering (Robotics), Guangdong Technion - Israel Institute of Technology, Shantou, Guangdong 515063, China.
Hypothesis: Current models for receding contact angles of Cassie-Baxter state droplets on textured hydrophobic substrates are applicable only to a specific structural type, e.g., pillar (above which a droplet has isolated contact line and continuous liquid-vapor interface) or pore (continuous contact line and isolated liquid-vapor interface), signifying a lack of universality.
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