AI Article Synopsis
- The mitochondrial inner membrane includes two sections: the inner boundary membrane and the cristae membrane, linked by crista junctions.
- Mitofilin/Fcj1 is crucial for the formation of these junctions, and our study shows it plays a dual role by being part of a large complex with five other proteins called MINOS, which maintains the connection between the cristae and inner boundary membranes.
- Additionally, mitofilin helps in protein import to the mitochondria by interacting with the outer membrane, highlighting its importance in both mitochondrial structure and protein synthesis.
Article Abstract
The mitochondrial inner membrane consists of two domains, inner boundary membrane and cristae membrane that are connected by crista junctions. Mitofilin/Fcj1 was reported to be involved in formation of crista junctions, however, different views exist on its function and possible partner proteins. We report that mitofilin plays a dual role. Mitofilin is part of a large inner membrane complex, and we identify five partner proteins as constituents of the mitochondrial inner membrane organizing system (MINOS) that is required for keeping cristae membranes connected to the inner boundary membrane. Additionally, mitofilin is coupled to the outer membrane and promotes protein import via the mitochondrial intermembrane space assembly pathway. Our findings indicate that mitofilin is a central component of MINOS and functions as a multifunctional regulator of mitochondrial architecture and protein biogenesis.
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| http://dx.doi.org/10.1016/j.devcel.2011.08.026 | DOI Listing |
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