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Anti-fibrotic and anti-stricture effects of biodegradable biliary stents braided with dexamethasone-impregnated sheath/core structured monofilaments.
Acta Biomater
April 2024
Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea; Division of Bio-Medical Science and Technology, University of Science and Technology, Daejeon 34113, Republic of Korea. Electronic address:
Endoscopic biliary stent insertion has been widely used for the treatment of benign biliary stricture (BBS). Thus, the development of stent materials in the perspectives of structure, mechanical properties, and biocompatibility has been also studied. However, conventional metal and plastic stents have several disadvantages, such as repeated procedures to remove or exchange them, dislodgment, restenosis, biocompatibility, and poor mechanical properties.
View Article and Find Full Text PDFRecent developments in antibacterial or antibiofilm compound coating for biliary stents.
Colloids Surf B Biointerfaces
November 2022
Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu province, Gansu Provincial Hospital, 730000 Lanzhou, PR China; The First School of Clinical Medicine, Lanzhou University, 730000 Lanzhou, PR China. Electronic address:
Cholestasis of the indwelling biliary stents usually leads to stone recurrence after endoscopic retrograde cholangio pancreatoraphy (ERCP). Biliary stents, including metallic and none-degradable plastic stents are widely used in clinical settings due to their many excellent properties. However, conventional biliary stents still suffer from poor antibacterial activity and anti-bile-adhesion, which lead to injured, local fibroblasts proliferating.
View Article and Find Full Text PDFA narrative review of progress in airway stents.
J Thorac Dis
May 2022
Department of Respiratory and Critical Care Medicine, Shanghai Changhai Hospital, the First Affiliated Hospital of Second Military Medical University, Shanghai, China.
Article Synopsis
- Airway stents are primarily used for patients with malignant airway strictures but are also applicable for benign conditions like stenosis and malacia, with ongoing advancements in stent technology.
- A comprehensive review of studies from 1964 to 2021 highlights various stent types, including metallic, silicone, drug-eluting, biodegradable, radioactive, and 3D-printed options, showing promise for enhanced safety and efficacy but remaining in early developmental stages.
- The potential combination of 3D printing and biodegradable materials is seen as a future direction to address the limitations of traditional stents and improve clinical applications.
Biodegradable Stent with mTOR Inhibitor-Eluting Reduces Progression of Ureteral Stricture.
Int J Mol Sci
May 2021
Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Chiayi 613016, Taiwan.
In this study, we investigated the effect of mTOR inhibitor (mTORi) drug-eluting biodegradable stent (DE stent), a putative restenosis-inhibiting device for coronary artery, on thermal-injury-related ureteral stricture in rabbits. In vitro evaluation confirmed the dose-dependent effect of mTORi, i.e.
View Article and Find Full Text PDFAirway stenting: Technological advancements and its role in interventional pulmonology.
Respirology
September 2020
Thoracic Oncology, Pleural Disease and Interventional Pulmonology Department, North University Hospital, Marseille, France.
AS offers rapid and sustained relief of symptoms in most patients treated for malignant or benign CAO and can also be curative in itself in cases of benign tracheobronchial stenosis. In the past 30 years, this field has seen significant progress, from the misuse of vascular non-covered metallic stents to the development of silicone airway stents with an increasingly large panel of shapes and of hybrid, partially or fully covered, SEMS customized to the airways. This study aims to offer an overview on: (i) the respective advantages and drawbacks of these two main categories of devices; (ii) the main indications for AS and the rationale behind the choice of stent in each situation; and (iii) the main promises borne from the progress made in the field in the past few years, including the development of drug-eluting, biodegradable or patient-specific customized AS.
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