AI Article Synopsis
- The study examined hormone-related risk factors for meningiomas, finding no significant increased risk for women using oral contraceptives or hormone therapy.
- Among males, a notable increase in risk was linked to androgen analogues and high-dose cyproterone acetate, but these cases were rare.
- Overall, the findings suggest that female hormone use doesn’t contribute to meningioma risk, while the risk in males associated with certain hormones needs more research.
Article Abstract
Background: The aetiology of meningiomas is largely unknown although hormones have been suggested to play a role.
Methods: A cohort study was performed to evaluate hormone-related factors associated with meningioma. Patients (12-89 years) with a first diagnosis of meningioma (January 1996-June 2008) were identified from The Health Improvement Network UK primary care database and age- and sex-matched to controls (n=10000) from the same cohort. Odds ratios (ORs) were calculated following a nested case control analysis using unconditional logistic regression.
Results: In total, 745 patients with meningioma were identified from a study population of 2171287. No significantly increased risk of meningioma was found among female users of oral contraceptives (OR: 1.15; CI: 0.67-1.98), hormone replacement therapy (OR: 0.99; CI: 0.73-1.35) or low-dose cyproterone acetate (CPA; OR: 1.51; CI: 0.33-6.86) compared with non-users. There was a significantly increased risk of meningioma among male users of androgen analogues (OR: 19.09; CI: 2.81-129.74) and among users of high-dose CPA (OR: 6.30; CI: 1.37-28.94) compared with non-users, however there were only three cases currently using these drugs. No significant association was found between meningioma and prostate, breast, or genital cancers.
Conclusions: Our results do not support a role for exogenous hormone use by females in meningioma development. The risk in males was only observed with high-dose, short-term (<1 year) therapy.
Impact: While hormonal cancers and therapies are not associated with meningioma in females, the risk in males requires further investigation.
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| http://dx.doi.org/10.1016/j.canep.2011.08.003 | DOI Listing |
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