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HeberNasvac: Development and Application in the Context of Chronic Hepatitis B.
Euroasian J Hepatogastroenterol
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Department of Vaccines, Center for Genetic Engineering and Biotechnology (CIGB), Havana, Cuba.
Unlabelled: The immune system plays a central role in controlling acute hepatitis B infection and in patients resolving chronic hepatitis B (CHB). Given that 221 million (75%) of CHB patients reside in low- and middle-income countries, the development of a vaccine with therapeutic properties represents a rational and cost-effective approach more than a romantic endeavor. This review systematically analyzes the key variables related to the safety, efficacy, and effectiveness of CHB treatments.
View Article and Find Full Text PDFGenerativity as a heuristic for impact-driven scholars addressing grand challenges.
Strateg Organ
February 2025
In this contribution, we theorize generativity as a heuristic for impact-driven management scholars seeking to address grand challenges through research. We use generativity to connote the engagement of diverse actors in pluralistic inquiry to create conditions for future flourishing. Our theorization applies a pragmatist worldview and builds on insights from the multidisciplinary literature on generativity to envisage researchers as agents of care, collective learning, and transformative change.
View Article and Find Full Text PDFIdentifying biomarker-driven subphenotypes of cardiogenic shock: analysis of prospective cohorts and randomized controlled trials.
EClinicalMedicine
January 2025
University of Paris Cité, Inserm UMR-S 942, Cardiovascular Markers in Stress Conditions (MASCOT), Paris, France.
Background: Cardiogenic shock (CS) is a heterogeneous clinical syndrome, making it challenging to predict patient trajectory and response to treatment. This study aims to identify biological/molecular CS subphenotypes, evaluate their association with outcome, and explore their impact on heterogeneity of treatment effect (ShockCO-OP, NCT06376318).
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Cancer Research in the Age of Spatial Omics: Lessons from IMAXT.
Cancer Discov
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CRUK Cambridge Institute, University of Cambridge. Li Ka Shing Centre, Cambridge, United Kingdom.
The Imaging and Molecular Annotation of Xenografts and Tumors Cancer Grand Challenges team was set up with the objective of developing the "next generation" of pathology and cancer research by using a combination of single-cell and spatial omics tools to produce 3D molecularly annotated maps of tumors. Its activities overlapped, and in some cases catalyzed, a spatial revolution in biology that saw new technologies being deployed to investigate the roles of tumor heterogeneity and of the tumor micro-environment. See related article by Stratton et al.
View Article and Find Full Text PDFConquering Overtreatment of DCIS: Lessons from PRECISION.
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Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands.
As we cannot reliably distinguish indolent, low-risk ductal carcinoma in situ (DCIS) from potentially progressive, high-risk DCIS, all women with DCIS diagnosis undergo intensive treatment without any benefit. The PREvent ductal Carcinoma In Situ Invasive Overtreatment Now team was established to unravel DCIS biology and develop new multidisciplinary approaches for accurate risk stratification to tackle the global problem of DCIS overdiagnosis and overtreatment. See related article by Bressan et al.
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