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Discovery of D-Ring-Contracted Artemisinin as a Potent Hydrophobic Tag for Targeted Protein Degradation.
J Med Chem
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Key laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), Guizhou Engineering Laboratory for Synthetic Drugs, School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, PR China.
The relentless pursuit of innovative hydrophobic tags remains a formidable challenge within the realm of targeted protein degradation. Herein, we have uncovered the remarkable potential of D-ring-contracted artemisinin as a potent hydrophobic tag that demonstrates exceptional degradation efficiency. We have crafted a series of conjugates by fusing D-ring-contracted artemisinin with raloxifene, and among these, has emerged as a promising candidate for degrading estrogen receptor α (ERα).
View Article and Find Full Text PDFLight People: Prof. Henry Snaith's (FRS) perovskite optoelectronics journey.
Light Sci Appl
January 2025
Executive Management College of CHN ENERGY, No.7 Binhe Avenue, North District of Future Science City, Changping District, Beijing, 102211, China.
In 2012, Prof. Henry Snaith demonstrated the first solid-state perovskite solar cell (PSC) with an efficiency of 10.9%, igniting a surge of interest and research into perovskite materials for their potential to revolutionize the photovoltaic (PV) industry.
View Article and Find Full Text PDFComparative analysis of backbone atom cross-correlation matrices and folding dynamics of amyloid fibril and its complexes with novel biosurfactants isolated from Bacillus strain: a binding free energy calculation (mM-PBSA) and MD simulation approach.
J Biomol Struct Dyn
December 2024
Centre for Biotechnology, Siksha 'O' Anusandhan (Deemed to Be University), Bhubaneswar, Odisha, India.
In the relentless pursuit of unraveling the intricate pathophysiology of Alzheimer's disease (AD), amyloid β (Aβ) proteins emerge as focal points due to their pivotal role in disease progression. The pathological hallmark of AD involves the aberrant aggregation of Aβ peptides into amyloid fibrils, precipitating a cascade of neurodegenerative events culminating in cognitive decline and neuronal loss. This study adopts a computational framework to investigate the potential therapeutic efficacy of novel biosurfactants (BS) in mitigating Aβ fibril formation.
View Article and Find Full Text PDFThe relentless pursuit of understanding matter at ever-finer scales has pushed optical microscopy to surpass the diffraction limit and realize super-resolution microscopy, which enables visualizing structures shorter than the wavelength of the light emitted by the sample. In the present work, we harnessed extreme ultraviolet beams to create sub-μm grating structures, which were revealed by extreme ultraviolet structured illumination microscopy. We establish that the resolution extension is achievable in the extreme ultraviolet, thereby opening the door to significant resolution enhancement, mainly defined by the wavelength employed.
View Article and Find Full Text PDFAs the global pursuit of renewable energy intensifies and the demand for offshore wind turbines rises, a comprehensive understanding of the coupling response characteristics of offshore monopiles, seabed, and waves in various sea conditions has become increasingly crucial. This paper reports on a wave flume experiment and seeks to contribute valuable insights by examining the coupling response of offshore monopiles, seabed, and waves exerting a relentless influence. The experimental results indicate that the impact of waves on monopiles is significant: there is greater pressure on the wave facing surface of the offshore piles than the other faces, and the pressure increases with increased wave height as well as the height of the monopile.
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