AI Article Synopsis
- Deep brain stimulators (DBS) are gaining attention as a treatment for patients with epilepsy, particularly those whose seizures are not controlled by medication.
- Thalamic DBS has shown promising results, leading to significant reductions in seizure frequency and improvements in patients' quality of life.
- More research is needed to determine which specific patient groups would benefit most from DBS and to find the best settings for the stimulation.
Article Abstract
With the growing applications for deep brain stimulators (DBS) in recent years, interest in using DBS as an option for patients with epilepsy has increased. Thalamic DBS appears to be a viable minimally invasive treatment for patients experiencing medically intractable seizures. Thalamic DBS has been associated with significant reduction in seizure frequency and an improvement in overall quality of life, especially in patients who have failed maximal antiepileptic drugs or other surgical alternatives. However, further work is necessary to identify the subgroups of patients experiencing medically intractable seizures who may benefit from DBS, and also to indentify optimal stimulation parameters and mode of stimulation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.nec.2011.07.006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Seizure Detection and Lateralization Using Thalamic Deep Brain Stimulator Recordings.
J Clin Neurophysiol
December 2024
Department of Neurology, Mayo Clinic, Rochester, Minnesota, U.S.A.; and.
The lack of reliable seizure detection remains a significant challenge for epilepsy care. A clinical deep brain stimulation (DBS) system provides constrained ambulatory brain recordings; however, limited data exist on the use of DBS recordings for seizure detection and lateralization. We present the case of an 18-year-old patient with drug-resistant focal epilepsy, who had seizure detection and lateralization by DBS recordings.
View Article and Find Full Text PDFRevolutionizing treatment for disorders of consciousness: a multidisciplinary review of advancements in deep brain stimulation.
Mil Med Res
December 2024
Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200433, China.
Among the existing research on the treatment of disorders of consciousness (DOC), deep brain stimulation (DBS) offers a highly promising therapeutic approach. This comprehensive review documents the historical development of DBS and its role in the treatment of DOC, tracing its progression from an experimental therapy to a detailed modulation approach based on the mesocircuit model hypothesis. The mesocircuit model hypothesis suggests that DOC arises from disruptions in a critical network of brain regions, providing a framework for refining DBS targets.
View Article and Find Full Text PDFA critical role of action-related functional networks in Gilles de la Tourette syndrome.
Nat Commun
December 2024
Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Gilles de la Tourette Syndrome (GTS) is a chronic tic disorder, characterized by unwanted motor actions and vocalizations. While brain stimulation techniques show promise in reducing tic severity, optimal target networks are not well-defined. Here, we leverage datasets from two independent deep brain stimulation (DBS) cohorts and a cohort of tic-inducing lesions to infer critical networks for treatment and occurrence of tics by mapping stimulation sites and lesions to a functional connectome derived from 1,000 healthy participants.
View Article and Find Full Text PDFChanges in Functional Connectivity Relate to Modulation of Cognitive Control by Subthalamic Stimulation.
Hum Brain Mapp
December 2024
Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Subthalamic (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) patients not only improves kinematic parameters of movement but also modulates cognitive control in the motor and non-motor domain, especially in situations of high conflict. The objective of this study was to investigate the relationship between DBS-induced changes in functional connectivity at rest and modulation of response- and movement inhibition by STN-DBS in a visuomotor task involving high conflict. During DBS ON and OFF conditions, we conducted a visuomotor task in 14 PD patients who previously underwent resting-state functional MRI (rs-fMRI) acquisitions DBS ON and OFF as part of a different study.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!