Background: The goal of this study was to evaluate whether a live attenuated poliovirus vaccine (OPV) has clinically relevant interfering effect with non-polio infections causing otitis media in young children.
Methods: Open trial in which the intervention group (64 children) received OPV at the age of 2, 3, 6 and 12 months. The control group (250 children) received IPV (inactivated polio vaccine) at the age of 6 and 12 months. Clinical symptoms were recorded by a questionnaire at the age of 3, 6, 12, 18 and 24 months.
Results: Otitis media episodes were less frequent in the OPV than in the control group. A significant difference was seen at the age of 6-18 months (IRR=0.76 [95% CI 0.59-0.94], P=0.011) and was particularly clear among children, who attended daycare (IRR 0.37 [95% CI 0.19-0.71], P=0.003).
Conclusions: OPV provides some protection against otitis media. This effect may be mediated by viral interference with non-polio viruses.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127548 | PMC |
| http://dx.doi.org/10.1016/j.vaccine.2011.09.015 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Does Palatoplasty Technique Impact Resolution of Eustachian Tube Dysfunction?
Cleft Palate Craniofac J
January 2025
Department of Otolaryngology - Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Objective: To determine whether palatoplasty technique affects the resolution of eustachian tube dysfunction and postoperative speech outcomes in children with cleft palate (CP).
Design: Retrospective cohort.
Setting: Multidisciplinary cleft and craniofacial clinic at a tertiary care center.
Reducing antibiotic duration for acute otitis media: clinician, administrator, and parental insights to inform implementation of system-level interventions.
Antimicrob Steward Healthc Epidemiol
January 2025
Center for Health Systems Research, Office of Research, Denver Health and Hospital Authority, Denver, CO, USA.
Objective: This qualitative study aimed to understand facilitators and barriers to implementation of interventions to improve guideline-concordant antibiotic duration prescribing for pediatric acute otitis media (AOM).
Design: Clinicians and clinic administrators participated in semi-structured qualitative interviews, and parents of children 2 years of age or older with a recent diagnosis of AOM participated in focus groups. The Practical Robust Implementation and Sustainability Model (PRISM) guided the study.
Simplified process for preparing native and depolymerized capsular polysaccharides of Streptococcus pneumoniae.
Carbohydr Polym
March 2025
Beijing Minhai Biotechnology Co. Ltd, Beijing 102600, China. Electronic address:
Streptococcus pneumoniae is a major pathogen of bacterial pneumonia, meningitis, sepsis, and otitis media. The pathogenicity of this bacterium is largely attributed to its polysaccharide capsule, a protective layer around bacterial cell that enables bacteria to resist against host defense. Capsular polysaccharides (CPSs) of S.
View Article and Find Full Text PDFBilateral squamous cell carcinoma of the temporal bone: A report of two cases and a systematic review of the literature.
J Otol
October 2024
Amsterdam UMC Location Vrije Universiteit Amsterdam, Otorhinolaryngology, De Boelelaan 1117, Amsterdam, the Netherlands.
Objective: two new cases of temporal bone squamous cell carcinoma (TBSCC) with a bilateral occurrence are presented. Furthermore, a review of the literature was performed and the yearly incidence was calculated.
Methods: A systematic review of the literature was conducted using PRISMA guidelines.
Bacterial etiologies, antimicrobial susceptibility profiles and associated factors among patients with otitis media referred to Nekemte Public Health Research and Referral Laboratory Center, Western Ethiopia: A cross-sectional study.
BMC Microbiol
January 2025
Department of Pharmacy, College of Health Sciences, Salale University, P.O. Box 245, Fitche, Ethiopia.
Background: Otitis media is among the leading causes of illnesses responsible for causing hearing problems and adding significant costs to the public health system. Bacteria are the most common causative agents for otitis media. Currently, there is little information on the prevalence and antimicrobial susceptibility patterns of pathogenic bacterial isolates from patients with otitis media in Ethiopia.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!