SEM-induced shrinking of solid-state nanopores for single molecule detection.

Nanotechnology

School of Biomedical Engineering and Health Science, Drexel University, Philadelphia, PA 19104, USA.

Published: October 2011

We have investigated the mechanism by which the diameter of solid-state nanopores is reduced by a scanning electron microscope. The process depends on beam parameters such as the accelerating voltage and electron flux and does not involve simple electron-beam-induced deposition of hydrocarbon contaminants. Instead, it is an energy-dependent process that involves material flow along the surface of the nanopore membrane. We also show that pores fabricated in this manner can detect double stranded DNA.

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http://dx.doi.org/10.1088/0957-4484/22/42/425302DOI Listing

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