Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/278743a0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cross-reactivity of antigenic binding sites of antiphosphatidylserine/prothrombin antibodies in patients with pregnancy loss and epidermal growth factor.
J Reprod Immunol
February 2025
Laboratory for Recurrent Pregnancy Loss, Sugi Women's Clinic, 2-12-1-7 F Shinyokohama, Kohoku, Yokohama, Kanagawa 222-0033, Japan.
Background: Epidermal growth factor (EGF) protein family is essential for implantation and maintenance of normal pregnancy. Results of our previous study on the high incidence of autoantibodies to EGF in patients with pregnancy loss indicated a strong association between EGF autoantibodies and antiphosphatidylserine/prothrombin antibodies (aPS/PT), which are observed in the plasma of patients with thrombosis and adverse pregnancy outcomes.
Objectives: To investigate the association between EGF autoantibodies and aPS/PT in patients with pregnancy loss.
Bactogram: Spatial Analysis of Bacterial Colonisation in Epidermal Wounds.
Exp Dermatol
December 2024
Division of Dermatology and Venereology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Skin barrier damage and subsequent development of harmful microbiota contribute to conditions such as wound infections, atopic dermatitis and chronic wounds, which impact millions of people globally and pose a significant economic burden on healthcare systems. Established microbial sampling methods, such as swabs and tissue biopsies, provide limited information on the spatial distribution of bacteria. We here describe a new method that produces a visual map of the distribution of cultivable bacteria, denoted 'Bactogram', across the whole wound and surrounding skin, suitable for image-based quantification.
View Article and Find Full Text PDFIdentification of an osteopontin structural element for the restoration of a normal endometrial epidermal growth factor (EGF) profile determined by the EGF concentration on day 3 of estrous cycle and pregnancy outcome in repeat breeder dairy cows.
Theriogenology
January 2025
Laboratory of Theriogenology, Department of Clinical Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan. Electronic address:
The loss of a cyclic change with two peaks of increased endometrial epidermal growth factor (EGF) concentration on days 2-4 and 13-14 during the estrous cycle has been linked to low fertility in repeat breeder (RB) cows. We have shown that an intravaginal infusion of osteopontin (OPN) restored the EGF profile in RB cows. The present study aimed to determine a structural element of OPN to restore the normal EGF profile and fertility.
View Article and Find Full Text PDFProtease activated receptor-1 regulates mixed lineage kinase-3 to drive triple-negative breast cancer tumorigenesis.
Cancer Lett
October 2024
Department of Surgery, Division of Surgical Oncology, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA; University of Illinois Hospital and Health Sciences System Cancer Center, University of Illinois at Chicago, Chicago, IL, 60612, USA; Research Unit, Jesse Brown VA Medical Center, Chicago, IL, 60612, USA. Electronic address:
Triple-negative breast cancer (TNBC) is difficult to treat breast cancer subtype due to lack or insignificant expressions of targetable estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2). Therefore, finding a targetable protein or signaling pathway in TNBC would impact patient care. Here, we report that a member of the Mixed Lineage Kinase (MLK) family, MLK3, is an effector of G-protein-coupled protease-activated receptors 1 (PAR1) and targeting MLK3 by a small-molecule inhibitor prevented PAR1-mediated TNBC tumorigenesis.
View Article and Find Full Text PDFTheoretical exploring of potential mechanisms of antithrombotic ingredients in danshen-chishao herb-pair by network pharmacological study, molecular docking and zebrafish models.
Chin Med
July 2024
School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China.
Article Synopsis
- Scientists studied a traditional Chinese medicine made of two herbs, DS and CS, to see how it prevents blood clots (thrombosis) using zebrafish.
- They tested different amounts of DS and CS to find out which worked best and discovered that a mix of two ingredients (PF and SAA) worked even better together.
- The research identified important proteins in the body that help explain how this herbal combination prevents blood clots and is connected to processes like fat metabolism.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!