Aim: Functional nuclear medicine imaging techniques have become particularly important in the diagnosis of osteomyelitis. The aim of our study was to perform a meta-analysis to obtain a reliable estimate of the diagnostic performance of fluorodeoxyglucose-positron emission tomography (FDG-PET), three-phase bone scintigraphy, leukocyte scintigraphy, and monoclonal antigranulocyte antibody (MOAB) scintigraphy in the assessment of suspected osteomyelitis and to perform pairwise comparisons of the diagnostic accuracy between these different imaging modalities.
Patients And Methods: A total of 23 studies representing 851 examinations that were published from January 1980 to October 2010 were reviewed. These studies evaluated the role of FDG-PET, three-phase bone scintigraphy, leukocyte scintigraphy, and MOAB scintigraphy in the assessment of suspected osteomyelitis. Systematic methods were used to identify, select, and evaluate the methodological quality of the studies and to summarize the overall findings of sensitivity and specificity. Two-sample Z-tests were conducted to evaluate for differences in sensitivity, specificity, area under the curve (AUC), and the Q* index between any two diagnostic modalities.
Results: The FDG-PET had a pooled sensitivity of 0.923, specificity of 0.920, and AUC of 0.9666, whereas for bone scintigraphy, the corresponding values were 0.827, 0.446, and 0.6514, respectively, for leukocyte scintigraphy, the corresponding values were 0.742, 0.881, and 0.9139, respectively, and for MOAB, the corresponding values were 0.883, 0.705, and 0.8897, respectively. Our meta-analysis did not find statistically significant differences in the sensitivity, specificity, AUC, and Q* index between FDG-PET and leukocyte scintigraphy.
Conclusion: Leukocyte scintigraphy can be used with satisfactory diagnostic accuracy for detecting osteomyelitis when positron emission tomography systems are not available. The FDG-PET appears to be superior in terms of accuracy compared with other radionuclide imaging modalities.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/MNM.0b013e32834b455c | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Detection of Gram-Ghost Bacilli and Additional Ziehl-Neelsen Stain for the Early Diagnosis of Driveline Infection: A Case Report.
Transplant Proc
December 2024
Department of Transplant Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan. Electronic address:
Background: Driveline infections (DLI) caused by nontuberculous mycobacteria (NTM) in patients with implantable left ventricular assist devices (iLVAD) are rare but fatal, requiring early diagnosis and appropriate treatment. Herein, we present a rare case of DLI caused by Mycobacterium chelonae, which was promptly diagnosed using Gram stain and Ziehl-Neelsen stain and followed a favorable clinical course.
Case Presentation: A 51-year-old man with an iLVAD complicated by DLI was admitted to our center.
Magnetic nanoradiotracers for targeted neutrophil detection in pulmonary arterial hypertension.
J Nanobiotechnology
November 2024
Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Donostia, 20014, Spain.
Background: Pulmonary arterial hypertension (PAH) is a severe disease characterized by elevated blood pressure in the pulmonary artery that can ultimately damage the right ventricle of the heart. PAH is pathophysiologically heterogeneous, which makes early diagnosis and treatment difficult. Inflammation is thought to be an important factor in the development and progression of this disease and may explain some of the observed interindividual differences.
View Article and Find Full Text PDF[Tc]-PentixaTec SPECT/CT for Imaging of Chemokine Receptor 4 Expression After Myocardial Infarction.
Circ Cardiovasc Imaging
November 2024
Nuclear Medicine, Faculty of Medicine (A.L., R.A.B., C.H.P., M.K., G.W., C.L.), University of Augsburg, Germany.
Article Synopsis
- The study explores the use of a novel SPECT tracer, [Tc]-PentixaTec, to visualize CXCR4-positive immune cells in patients after an acute myocardial infarction (AMI).
- In a retrospective analysis of 9 AMI patients, increased CXCR4 expression was found in areas with reduced blood flow, indicating localized inflammation in the heart.
- The findings suggest that CXCR4 imaging could serve as a potential tool for assessing inflammation post-AMI, even though there was no significant correlation with common blood markers of heart damage.
Molecular imaging in experimental pulmonary fibrosis reveals that nintedanib unexpectedly modulates CCR2 immune cell infiltration.
EBioMedicine
December 2024
Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA; Department of Radiology, Washington University School of Medicine, Saint Louis, MO, USA. Electronic address:
Background: Pulmonary fibrosis is a challenging clinical problem with lung pathology featuring immune cell infiltrates, fibroblast expansion, and matrix deposition. Molecular analysis of diseased lungs and preclinical models have uncovered C-C chemokine receptor type 2 (CCR2)+ monocyte egress from the bone marrow into the lung, where they acquire profibrotic activities. Current drug treatment is focused on fibroblast activity.
View Article and Find Full Text PDFGenome-wide transcriptome analysis of Aβ deposition on PET in a Korean cohort.
Alzheimers Dement
December 2024
Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Article Synopsis
- The study addresses the lack of ethnic diversity in Alzheimer's research, focusing on Asian populations, particularly Koreans, to enhance understanding of the disease.
- RNA sequencing was conducted on blood samples to analyze gene expression and its relation to amyloid beta (Aβ) deposition, leading to the identification of 265 dysregulated genes associated with Aβ.
- Findings suggest that certain genes linked to Aβ deposition are enriched in natural killer cell-mediated immunity, highlighting potential new avenues for diagnostics and therapies in Alzheimer's disease.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!