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Similar Publications

Recurrent Pleomorphic Adenoma Presenting as a Giant Parapharyngeal Mass.

Ear Nose Throat J

January 2025

Department of Otolaryngology-Head and Neck Surgery, Al-Bairuni University Hospital, Faculty of Medicine, Damascus University, Damascus, Syria.

Article Synopsis
  • Pleomorphic adenoma (PA) is a common benign tumor of the salivary glands, often recurs and can extend into the parapharyngeal space (PPS), complicating treatment.
  • A 45-year-old male with a history of limited PA excision presented with a growing neck mass and related symptoms; MRI revealed a large tumor in the PPS.
  • Surgical removal involved a specialized neck approach, and the patient received postoperative radiotherapy, emphasizing the complexities and careful planning required for effective management of PPS tumors.
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Rationale: Primary sarcomatoid carcinoma of the trachea (PSCT) is a rare malignant tumor of the lower respiratory tract. Pathological types of tracheal sarcomatoid carcinoma (TSC)s include pleomorphic carcinomas, giant cell carcinomas, spindle cell carcinomas, pulmonoblastomas, and carcinosarcomas. At present, there are limited reports on PSCT, and pathologists lack sufficient knowledge about it.

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Prostate cancer (PCa) is the most common solid malignancy in men in the UK. Pleomorphic giant cell carcinoma (PGCC) is a rare, aggressive variant of prostate adenocarcinoma. PGCC is associated with a poor prognosis and high Gleason-grade characteristics, often occurring in patients with a history of PCa treatment.

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Non-Hodgkin CD30+ T-cell lymphoproliferative disease encompasses three subgroups, one of which is primary cutaneous anaplastic large T-cell lymphoma (PC-ALCL). It is distinguished by the presence of giant anaplastic cells with pleomorphism and widespread CD30 positivity. The case of a 58-year-old female is presented who reported to the Eye Department of Jinnah Post-Graduate Medical Centre (JPMC) on 18th January, 2023 with a three-month history of rapidly enlarging, non-tender, ulcerated lesion on the lower eyelid of the right eye.

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