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Impact of therapeutic doses of prednisolone and other glucocorticoids on insulin secretion from human islets.
Ann Endocrinol (Paris)
December 2024
University of Lille, CHU de Lille, Inserm U1190, EGID, Institut Pasteur de Lille, 59000 Lille, France. Electronic address:
Introduction: Glucocorticoid-induced diabetes (GCID) is a prevalent health issue, generally attributed to insulin resistance. High doses of dexamethasone (DEX) are known to inhibit glucose-stimulated insulin secretion (GSIS), but the effects of lower doses, commonly used in chronic therapy, and equipotent doses of other glucocorticoids (GCs) such as hydrocortisone (HC) and prednisone (PRED) remain underexplored. This study aimed to investigate these effects in vitro, and explore variations between patients.
View Article and Find Full Text PDFCriteria for medication reconciliation in major orthopedic surgery in high-risk patients: A consensus based on the Delphi method.
Farm Hosp
November 2024
Luz Saúde, Lisboa, Portugal.
Background: Medication reconciliation is relevant in transitional care, however, given limited resources, it is necessary to identify the patients who benefit most from this activity.
Aim: To validate criteria to identify patients at high risk of medication errors undergoing major orthopedic surgery.
Method: Delphi Method in 3 phases, April-June 2023, to obtain consensus on the inclusion criteria, previously defined.
Efficacy of Lisosan G (fermented wheat) on reactive hypoglycemia after bariatric surgery.
Obes Res Clin Pract
December 2024
Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy. Electronic address:
Introduction: post-bariatric hypoglycemia (PBH) is considered a chronic complication after gastric bypass (RYGB) impacting roughly 30 % of patients. Current treatments often focus on nutritional interventions to reduce the frequency of episodes. This prospective study evaluated the effectiveness of Lisosan G (LG), a fermented wheat-based supplement added to the diet, in mitigating PBH episodes and elucidating its mechanism of action on the gut-pancreas axis.
View Article and Find Full Text PDFInsulin sensitivity, disposition index and insulin clearance in cystic fibrosis: a cross-sectional study.
Diabetologia
October 2024
Department of Clinical Studies-New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Kennett Square, PA, USA.
Aims/hypothesis: The aim of this study was to investigate insulin secretion, insulin sensitivity, disposition index and insulin clearance by glucose tolerance status in individuals with cystic fibrosis (CF) and exocrine pancreatic insufficiency.
Methods: In a cross-sectional study, we conducted an extended (ten samples) OGTT in individuals with pancreatic-insufficient CF (PI-CF). Participants were divided into normal glucose tolerance (NGT), early glucose intolerance (EGI), impaired glucose tolerance (IGT) and CF-related diabetes (CFRD) groups.
Hypertonicity during a rapid rise in D-glucose mediates first-phase insulin secretion.
Front Endocrinol (Lausanne)
July 2024
University of Washington Medicine Diabetes Institute, University of Washington, Seattle, WA, United States.
Introduction: Biphasic insulin secretion is an intrinsic characteristic of the pancreatic islet and has clinical relevance due to the loss of first-phase in patients with Type 2 diabetes. As it has long been shown that first-phase insulin secretion only occurs in response to rapid changes in glucose, we tested the hypothesis that islet response to an increase in glucose is a combination of metabolism plus an osmotic effect where hypertonicity is driving first-phase insulin secretion.
Methods: Experiments were performed using perifusion analysis of rat, mouse, and human islets.
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