AI Article Synopsis
- The study assessed growth and levels of IGF-1 and IGFBP-3 in infants with congenital heart disease (CHD) before and after surgery over one year.
- Acyanotic infants and those with pulmonary hypertension showed significant growth failure compared to controls.
- The findings revealed that preoperative IGF-1 and IGFBP-3 levels were lower in acyanotic infants, but these levels increased significantly by the third month and at one year, indicating they are strong indicators of nutritional status and that timely surgery is crucial for proper growth.
Article Abstract
The aim of this study is to evaluate growth and insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 (IGFBP-3) levels in infants with congenital heart disease (CHD) pre- and postoperatively over a period of a year. Anthropometric values and serum levels of IGF-1 and IGFBP-3 of 40 infants with CHD (20 cyanotic and 20 acyanotic) were compared with 32 healthy controls. Acyanotic infants and infants with pulmonary hypertension (PH) presented significantly more growth failure. Preoperatively, serum IGF-1 and IGFBP-3 levels were lower in the acyanotic group than the cyanotic and the control groups (p = 0.22; p < 0.01). The upward trend in IGF-1 and IGFBP-3 levels in this year-long study demonstrated that the values in the third month and the first year were higher than the preoperative values (p < 0.05). The parallel increase of weight gain and IGF-1, IGFBP-3 levels were the best evidence that these parameters are good nutritional indicators. Timing the corrective surgery before chronic malnutrition or PH develops is an important issue to maintain a normal growth for children with CHD.
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| http://dx.doi.org/10.1515/jpem.2011.061 | DOI Listing |
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