The study was designed to estimate activity of a series of anti-inflammatory markers (C-reactive protein (CRP), ceruloplasmin, haptoglobulin, interleukin (IL)-4, and IL-8) in the acute phase of acute coronary syndrome (ACS) and effect of beta-adrenoblocking therapy on their activity. The patients were divided into 2 groups: one was treated with beta-blocker metoprolol tartrate as a main component of ACS pharmacotherapy (n = 30), the other included the patients with absolute contraindications to bena-adrenoblockers (n = 15). Otherwise, patients of both groups received standard antianginal therapy including nitrates, anticoagulants, ACE inhibitors, and statins. The frequency of prescription of these drugs and coronary angioplasty was comparable in both groups. It was shown that patients with ACS have elevated levels of CRP, haptoglobulin and prooxidant marker ceruloplasmin.
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The study was designed to estimate activity of a series of anti-inflammatory markers (C-reactive protein (CRP), ceruloplasmin, haptoglobulin, interleukin (IL)-4, and IL-8) in the acute phase of acute coronary syndrome (ACS) and effect of beta-adrenoblocking therapy on their activity. The patients were divided into 2 groups: one was treated with beta-blocker metoprolol tartrate as a main component of ACS pharmacotherapy (n = 30), the other included the patients with absolute contraindications to bena-adrenoblockers (n = 15). Otherwise, patients of both groups received standard antianginal therapy including nitrates, anticoagulants, ACE inhibitors, and statins.
View Article and Find Full Text PDFAs many as 314 patients with functional class I-III ischemic heart disease (IHD) who had been placed on a long-term (3-year) monotherapy with propranolol were examined. Under a long-term administration of a beta-adrenoblocking agent no suppression has been seen of the contractile capability of the myocardium; there is noted an improvement in hemorheologic disturbances and a significantly greater improvement in the clinical course of the illness--it has been found out the therapy prevents transformation of angina of high effort to angina of low effort.
View Article and Find Full Text PDF[Blood lipids, lipid peroxidation and the effect on them of antianginal preparations in ischemic heart disease patients].
Eksp Klin Farmakol
August 1998
Department of Therapy, Pirogov Vinnitsa Medical University, Ukraine.
The origin and development of ischemic heart disease (IHD) is attended with activation of lipid free-radical oxidation facilitating further advancement of the disease and with decrease of the organism's antioxidant protection. The antianginal drugs which are used in IHD treatment differ in their effect on the blood lipid composition and their peroxidation. beta-Adrenoblocking agents may cause proatherogenic disorders of the blood lipid graph, this increases the risk of IHD advancement.
View Article and Find Full Text PDFCircadian variations of various parameters of the cardiointervalogram were observed in patients with ischemic cardiac disease. Analysis of the regularities found makes it possible to determine and predict the therapeutic efficacy of beta-adrenoblocking drugs and calcium antagonists.
View Article and Find Full Text PDF[The efficacy of proxodolol in patients with stable arterial hypertension].
Eksp Klin Farmakol
September 1994
The new original Russian drug proxodolol having alpha- and beta-adrenoblocking activities in a ratio of 1:100 was examined at Stages I and II of clinical trials. The drug was given to 29 male patients aged 30-63 years who suffered from Stages I and II persistent hypertensive disease with a baseline diastolic blood pressure of >95 mm Hg. Proxodolol as 10- and 40-mg tablets was demonstrated to be an effective antihypertensive agent, its antihypertensive effects being revealed in acute and chronic uses.
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