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STZ-induced hyperglycemia differentially influences mitochondrial distribution and morphology in the habenulointerpeduncular circuit.
Front Cell Neurosci
December 2024
Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, Friedman Brain Institute, New York, NY, United States.
Introduction: Diabetes is a metabolic disorder of glucose homeostasis that is a significant risk factor for neurodegenerative diseases, such as Alzheimer's disease, as well as mood disorders, which often precede neurodegenerative conditions. We examined the medial habenulainterpeduncular nucleus (MHb-IPN), as this circuit plays crucial roles in mood regulation, has been linked to the development of diabetes after smoking, and is rich in cholinergic neurons, which are affected in other brain areas in Alzheimer's disease.
Methods: This study aimed to investigate the impact of streptozotocin (STZ)-induced hyperglycemia, a type 1 diabetes model, on mitochondrial and lipid homeostasis in 4% paraformaldehyde-fixed sections from the MHb and IPN of C57BL/6 J male mice, using a recently developed automated pipeline for mitochondrial analysis in confocal images.
The additive effect of the stress hyperglycemia ratio on type 2 diabetes: a population-based cohort study.
Cardiovasc Diabetol
January 2025
Department of Radiology, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, China.
Background: The stress hyperglycemia ratio (SHR) has recently gained attention as a marker for acute hyperglycemia, which has been linked to adverse clinical outcomes. However, its independent role in the development of type 2 diabetes (T2D) remains understudied. This cohort study aimed to assess the association between SHR and the incidence of T2D.
View Article and Find Full Text PDFAssociation between thyroid dysfunction and insulin resistance: a retrospective cohort study.
BMJ Open
January 2025
Vibrant Sciences LLC, Santa Clara, California, USA.
Objective: To evaluate the association between thyroid disease and diabetes markers.
Design: Retrospective cohort study.
Setting: The study was conducted in a diagnostic setting where the primary care providers recommended the patients to test for thyroid and diabetes panels.
[Effect of ICT Use on Glycemic Control in Individuals with Type 2 Diabetes: A Systematic Review].
Rev Med Chil
July 2024
Facultad de Enfermería, Universidad Autónoma de Nuevo León, México.
Unlabelled: Information and communication technologies constitute a resource that can improve the effectiveness of programs focused on people with chronic diseases, especially those with type 2 diabetes mellitus, strengthening the care management provided by the nursing professional.
Aim: To evaluate the available evidence to understand the effects of information and communication technologies on glycaemic control in people with type 2 diabetes.
Material And Methods: Databases used for research were Web of Science, PubMed, and Scopus between January and March of 2023.
The Effect of Glycemic Control on Cardiovascular Disease Progression in Adults With Early-Onset Type 2 Diabetes: A Longitudinal Cohort Analysis.
Cureus
December 2024
Diagnostic Radiology, Lady Reading Hospital Peshawar, Peshawar, PAK.
Introduction Rising prevalence rates of type 2 diabetes mellitus (T2DM), particularly in younger populations, have made early-onset T2DM (diagnosed before age 40) an increasingly significant health concern. Early-onset T2DM is often associated with more rapid progression and increased complications, including cardiovascular disease (CVD). However, its specific impact on cardiovascular outcomes remains inadequately understood, particularly compared to T2DM in older populations.
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