AI Article Synopsis
- Eukaryotic chromosomes end with telomeres, which are crucial for cell growth and proliferation.
- Genome-wide studies have identified the Mediator complex as a key player in regulating telomere length and maintaining heterochromatin at telomeres.
- The Mediator complex, particularly its tail module, is essential for silencing telomeres by enhancing Sir protein binding, underscoring its specific role at telomeres rather than other genomic loci like HMR.
Article Abstract
Eukaryotic chromosome ends have a DNA-protein complex structure termed telomere. Integrity of telomeres is essential for cell proliferation. Genome-wide screenings for telomere length maintenance genes identified several components of the transcriptional regulator, the Mediator complex. Our work provides evidence that Mediator is involved in telomere length regulation and telomere heterochromatin maintenance. Tail module of Mediator is required for telomere silencing by promoting or stabilizing Sir protein binding and spreading on telomeres. Mediator binds on telomere and may be a component of telomeric chromatin. Our study reveals a specific role of Mediator complex at the heterochromatic telomere and this function is specific to telomeres as it has no effect on the HMR locus.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258146 | PMC |
| http://dx.doi.org/10.1093/nar/gkr757 | DOI Listing |
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