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Advances in the structural understanding of opioid allostery.
Trends Pharmacol Sci
January 2025
Department of Anesthesiology and Washington University Pain Center, Washington University School of Medicine, St Louis, MO, USA; Center for Clinical Pharmacology, Washington University School of Medicine, St Louis, MO, USA. Electronic address:
Activation of the μ opioid receptor (MOR) can give analgesia, but also has dangerous side effects. Drugs that target MOR through an allosteric site, meaning they bind outside of the usual pocket, present a novel mode of receptor activation with different pharmacology relative to orthosteric drugs. Recent structural studies give valuable new information on how allosteric modulators interact with MOR.
View Article and Find Full Text PDFOver-provisionals - Simplified chairside preoperative evaluation of esthetic and functional changes during full mouth rehabilitation.
J Indian Prosthodont Soc
January 2025
Department of Prosthodontics, Sri Ramachandra Dental College and Hospital, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
Prosthetic rehabilitation in multifaceted dental abnormality needs sequential planning to ensure adaptation of oral and associated musculature. Reduction of tooth structure before adaptation of oral and associated components may complicate the treatment modality if compliance of the musculature is poor. Hence, the fabrication of over-provisional in esthetic rehabilitation enables to assess of the success of the treatment plan preoperatively before invasive trials.
View Article and Find Full Text PDFBackground: Jailed wire (JW) in the side branch (SB) is recommended during coronary bifurcation provisional stenting, but real benefit is unsure. Our objective was to evaluate benefit of a JW technique in the CABRIOLET registry.
Methods: In CABRIOLET, including 500 patients, we compared the primary composite endpoint poor final SB angiographic result (TIMI flow
Parametrization of the dying brain: A case report from ICU bed-side EEG monitoring.
Neuroimage
January 2025
Department of Anesthesiology and Intensive Care Medicine, Technical University of Munich, School of Medicine and Health, 81675 Munich, Germany.
Background: Cortical high-frequency activation immediately before death has been reported, raising questions about an enhanced conscious state at this critical time. Here, we analyzed an electroencephalogram (EEG) from a comatose patient during the dying process with a standard bedside monitor and spectral parameterization techniques.
Methods: We report neurophysiologic features of a dying patient without major cortical injury.
Blackish Discoloration of Articular Cartilage during Total Knee Replacement; a Case Report.
J Orthop Case Rep
December 2024
Department of Orthopaedics, Government Medical College Trivandrum, Kerala, India.
Introduction: Alkaptonuria is a rare metabolic disorder that follows an autosomal recessive genetic inheritance pattern. It is distinguished by the buildup of homogentisic acid in tissues due to deficient homogentisic acid oxidase enzyme activity. The excess homogentisic acid is expelled through urine, darkening it on oxidation.
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