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| http://dx.doi.org/10.1002/anie.201104512 | DOI Listing |
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Acroamine A, a 2-Amino Adenine Alkaloid from the Marine Soft Coral and Its Semisynthetic Derivatives That Inhibit cAMP-Dependent Protein Kinase A Catalytic Subunit Alpha.
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Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.
A high throughput screen performed to identify catalytic inhibitors of the oncogenic fusion form of cAMP-dependent protein kinase A catalytic subunit alpha (J-PKAcα) found an individual fraction from an organic extract of the marine soft coral as active. Bioassay-guided isolation led to the identification of a 2-amino adenine alkaloid acroamine A (), the first secondary metabolite discovered from this genus and previously reported as a synthetic product. As a naturally occurring protein kinase inhibitor, to unambiguously assign its chemical structure using modern spectroscopic and spectrometric techniques, five -methylated derivatives acroamines A-A (-) were semisynthesized.
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Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, United States; Section of Clinical Chemistry, Division of Laboratory Medicine, Department of Pathology, Texas Children's Hospital, Houston, TX, United States. Electronic address:
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