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Absent skeletal uptake of (99m)Tc-hydroxymethylene diphosphonate in the presence of AL-type amyloidosis associated with multiple myeloma. | LitMetric

AI Article Synopsis

  • A 66-year-old woman with congestive heart failure suspected of having multiple myeloma underwent bone scintigraphy, which revealed unusual findings.
  • The scan showed absent skeletal uptake and increased uptake in the gastrointestinal tract, heart, and soft tissues, along with migration of the radionuclide to bilateral pleural effusions.
  • A histopathological exam confirmed she had AL-type amyloidosis related to multiple myeloma, marking a rare instance of these simultaneous findings where bone scintigraphy typically retains skeletal uptake in amyloidosis cases.

Article Abstract

A 66-year-old woman with congestive heart failure suspected to have multiple myeloma underwent bone scintigraphy. The bone scintigraphy using technetium-99m hydroxymethylene-diphosphonate showed the following interesting findings: absent skeletal uptake; increased gastrointestinal, myocardial, and soft tissue uptake; migration of radionuclide to bilateral pleural effusions. Histopathological examination revealed that the patient suffered from AL-type amyloidosis associated with multiple myeloma. Extraosseous uptake is often observed on bone scintigraphy in amyloidosis patients, but in many cases skeletal uptake is preserved. The simultaneous presentation of these findings is rare.

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Source
http://dx.doi.org/10.1007/s11604-011-0596-4DOI Listing

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