AI Article Synopsis
- The text provides an overview of challenges in creating low molecular weight inhibitors targeting protein-protein interactions, focusing on their design and development.
- Key areas include understanding protein-protein interfaces, techniques for characterizing these interfaces, and how this information aids in discovering and designing effective ligands.
- Specific case studies of inhibitors for proteins like p56lck kinase, ERK2, and S100B demonstrate promising drug-like properties, suggesting their potential as therapeutic agents.
Article Abstract
An overview of issues associated with the design and development of low molecular weight inhibitors of protein-protein interactions is presented. Areas discussed include information on the nature of protein-protein interfaces, methods to characterize those interfaces and methods by which that information is applied towards ligand identification and design. Specific examples of the strategy for the identification of inhibitors of protein-protein interactions involving the proteins p56lck kinase, ERK2 and the calcium-binding protein S100B are presented. Physical characterization of the inhibitors identified in those studies shows them to have drug-like and lead-like properties, indicating their potential to be developed into therapeutic agents.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173769 | PMC |
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