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Lung transplantation for diffuse pulmonary arteriovenous malformations associated with juvenile polyposis-hereditary hemorrhagic telangiectasia overlap syndrome: a case report.
Gen Thorac Cardiovasc Surg Cases
December 2024
Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan.
Background: Lung transplantation is a viable lifesaving option for patients with diffuse pulmonary arteriovenous malformations (AVMs). We present a case of diffuse pulmonary AVMs associated with juvenile polyposis and hereditary hemorrhagic telangiectasia (JP-HHT) that was successfully managed by lung transplantation.
Case Presentation: A 19-year-old woman developed severe hypoxemia due to pulmonary AVMs diagnosed at 4 years of age.
JAK2-V617F mutation among blood donors: A meta-analysis.
Saudi Med J
December 2024
From the Department of Preventive Medicine (Alsharif, Alharazi), Directorate of Health Affairs; from the Hematology Department (Mansory, Badawi), Faculty of Medicine, King Abdulaziz University; and from the Hematology Research Unit (Mansory, Badawi), King Fahd Medical Research Center, King Abdulaziz University, and from the Blood Transfusion Services Unit (Badawi), King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia.
Objectives: To systematically review evidence on the prevalence of the JAK2V617F (JAK2) mutation and polycythemia vera (PV) among all blood donors, focusing on those with elevated hematocrit. Although blood donors are generally healthy, considering a preclinical stage of myeloproliferative neoplasm, especially in those with polycythemia, is crucial. Evidence on managing these donors is limited.
View Article and Find Full Text PDFPost kidney transplant hematologic abnormalities and association of post-transplant anemia with graft function.
F1000Res
October 2024
Department of Nephrology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Article Synopsis
- Haematological abnormalities, particularly post-transplant anemia (PTA), are common among renal transplant recipients, with a peak prevalence of 98% in the first week post-surgery.
- Other issues included leukopenia, thrombocytopenia, and pancytopenia, often caused by medications and infections.
- Despite the high incidence of PTA initially, graft function was stable and similar among patients with and without anemia at six and 12 months post-transplant.
Selective Extrauterine Placental Perfusion in Monochorionic Twins Is Feasible-A Case Series.
Children (Basel)
October 2024
Division of Neonatology, Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
Article Synopsis
- Monochorionic (MC) twins face risks like twin-to-twin transfusion syndrome (TTTS) and anemia, leading to potential complications during preterm delivery.
- A study investigated a new method called selective extrauterine placental perfusion (EPP) with delayed umbilical cord clamping (DCC) for the donor twin, aiming to reduce anemia while still managing the recipient's condition.
- The results showed that using this EPP method in three cases successfully maintained healthy hemoglobin levels in the donor twins without needing blood transfusions, suggesting it could improve outcomes in similar situations.
Predictive Indicators and Outcomes of Pregnancies Affected by Stage I Twin-Twin Transfusion Syndrome Treated With Fetoscopic Laser Photocoagulation.
Prenat Diagn
November 2024
Maternal Fetal Medicine, Osaka Women's and Children's Hospital, Izumi, Japan.
Article Synopsis
- * Out of 272 twin pairs, the survival rates were very high, with 98% of at least one twin surviving and 85% for both, while 93% of recipient twins and 90% of donor twins survived.
- * The research identifies preoperative anemia-polycythemia sequence and arterio-arterial vascular anastomosis (AAA) as significant risk factors for mortality in donor twins after FLP, although the exact mechanisms of AAA need further investigation.
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