A new class of compounds that exhibit anti-norovirus activity in a cell-based system and embody in their structure a cyclosulfamide scaffold has been identified. The structure of the initial hit (compound 2a, ED(50) 4 μM, TD(50) 50 μM) has been prospected by exploiting multiple points of diversity and generating appropriate structure-activity relationships.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191538 | PMC |
| http://dx.doi.org/10.1016/j.bmc.2011.08.054 | DOI Listing |
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