Gait data are typically collected in multivariate form, so some multivariate analysis is often used to understand interrelationships between observed data. Principal Component Analysis (PCA), a data reduction technique for correlated multivariate data, has been widely applied by gait analysts to investigate patterns of association in gait waveform data (e.g., interrelationships between joint angle waveforms from different subjects and/or joints). Despite its widespread use in gait analysis, PCA is for two-mode data, whereas gait data are often collected in higher-mode form. In this paper, we present the benefits of analyzing gait data via Parallel Factor Analysis (Parafac), which is a component analysis model designed for three- or higher-mode data. Using three-mode joint angle waveform data (subjects×time×joints), we demonstrate Parafac's ability to (a) determine interpretable components revealing the primary interrelationships between lower-limb joints in healthy gait and (b) identify interpretable components revealing the fundamental differences between normal and perturbed subjects' gait patterns across multiple joints. Our results offer evidence of the complex interconnections that exist between lower-limb joints and limb segments in both normal and abnormal gaits, confirming the need for the simultaneous analysis of multi-joint gait waveform data (especially when studying perturbed gait patterns).
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http://dx.doi.org/10.1016/j.humov.2011.06.011 | DOI Listing |
Alzheimers Dement
December 2024
The Medical University of South Carolina, Charleston, SC, USA.
Background: Alzheimer's disease disproportionately affects women in the U.S., with two-thirds of individuals diagnosed being female.
View Article and Find Full Text PDFInt J Pharm
December 2024
Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge, CB3 0AS, UK. Electronic address:
Pharmaceutical tablets are routinely film-coated to improve appearance, reduce medication errors and enhance storage stability. Terahertz pulsed imaging (TPI) can be utilised to study the liquid penetration into the porous tablet matrix in real time. Using polymer-coated flat-faced tablets with anhydrous lactose or mannitol, we show that when the tablet matrix contains anhydrous material, the anhydrous form transforms to the solid-state hydrate form in the tablet core while the immediate release coating dissolves.
View Article and Find Full Text PDFSci Rep
December 2024
National Physical Laboratory, Teddington, UK.
We present the first controlled-environment measurements of the optical path-length change response of telecommunication submarine cables to active seismic and acoustic waves. We perform the comparison among integrated (optical interferometry) and distributed (distributed acoustic sensing, DAS) fibre measurements and ground truth data acquired by 58 geophones, 20 three-axis seismometers and 7 microphones. The comparison between different seismic acquisition methods is an essential step towards full validation and calibration of the data acquired using novel cable-based sensing techniques.
View Article and Find Full Text PDFBMJ Open
December 2024
Department of Paediatrics, Nara Medical University, Kashihara, Japan.
Introduction: Emicizumab prophylaxis is approved for people of all ages with haemophilia A (HA) including infants and children. Although previous studies have demonstrated the efficacy and tolerability of emicizumab in infants with HA, real-world data on emicizumab use in infants are limited. The Haemophilia A in Infancy and NewbOrns: multi-instituional prospective observational study to assess the efficacy anD safety of Emicizumab (HINODE) study aims to evaluate the coagulation potential and safety of emicizumab prophylaxis in infants with congenital HA from birth to <12 months of age.
View Article and Find Full Text PDFInterv Pain Med
December 2024
Department of Physical and Rehabilitation Medicine, University of Turku, Turku, Finland.
Background: Spinal Cord Stimulation (SCS) is a widely recognized treatment for Complex Regional Pain Syndrome (CRPS), particularly in cases where traditional methods are ineffective. This paper systematically reviews randomized controlled trials to analyze the efficacy of SCS, as well as Dorsal Root Ganglion (DRG) Stimulation in treating CRPS, focusing on its long-term effectiveness.
Methods: This systematic review focused exclusively on randomized controlled trials to assess a primary outcome of improvement in pain symptoms in patients diagnosed with CRPS.
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