AI Article Synopsis
- Toxoplasma gondii glycosylphosphatidylinositols (GPIs) interact with galectin-3, triggering TNF-α production in macrophages through Toll-like receptors 2 and 4.
- These GPIs lead to the synthesis of matrix metalloproteinase-9 in human macrophages, which is dependent on TNF-α.
- Additionally, this process results in the degradation of extracellular galectin-3.
Article Abstract
Toxoplasma gondii glycosylphosphatidylinositols (GPIs) bind to galectin-3 to induce TNF-α production in macrophages via Toll-like receptors 2 and 4. Here we show that T. gondii GPIs stimulate human macrophages to synthesize matrix metalloproteinase-9 in a TNF-α-dependent pathway and degrade extracellular galectin-3.
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| http://dx.doi.org/10.1016/j.imbio.2011.08.001 | DOI Listing |
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