Limited penetration of neuroprotective drug citicoline into the central nervous system (CNS) by systemic administration led to poor efficiency. A novel method of stereotactic drug delivery was explored to make citicoline bypass the blood brain barrier (BBB) and take effect by direct contact with ischemic neurons. A permanent middle cerebral artery occlusion (pMCAO) model of rats was prepared. To get the optimal conditions for citicoline administration by the novel stereotactic delivery pathway, magnetic resonance imaging (MRI) tracer method was used, and a dose-dependent effect was given. Examinations of MRI, behavior evaluation, infarct volume assessment and histological staining were performed to evaluate the outcome. This MRI-guided stereotactic delivery of citicoline resulted in a notable reduction (>80%) in infarct size and a delayed ischemic injury in cortex 12 hours after onset of acute ischemia when compared with the systematic delivery. The improved neuroprotective efficiency was realized by a full distribution of citicoline in most of middle cerebral artery (MCA) territory and an adequate drug reaction in the involved areas of the brain. Brain lesions of treated rats by stereotactic delivery of citicoline were well predicted in the lateral ventricle and thalamus due to a limited drug deposition by MRI tracer method. Our study realized an improved neuroprotective efficiency of citicoline by stereotactic delivery, and an optimal therapeutic effect of this administration pathway can be achieved under MRI guidance.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/10717544.2011.589084 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dosimetric investigation of couch rotation angles in non-coplanar VMAT plans for lung cancer SBRT.
Front Oncol
December 2024
Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Background: This study aimed to investigate the effect of couch rotation angles on non-coplanar volumetric modulated arc therapy (ncVMAT) plan for stereotactic body radiotherapy (SBRT) in lung cancer patients and to evaluate the feasibility of clinically applying ncVMAT for SBRT.
Methods: Twenty-four lung cancer patients with a single lesion eligible for SBRT were enrolled in the study. Seven dual partial-arc VMAT plans with varying couch angles were designed for every patient.
Technical note: Optimizing the deliverability of binary collimation-based SRS treatment for multiple metastases with multiple prescriptions.
Med Phys
January 2025
Department of Medical Physics, Nova Scotia Health, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada.
intra-arc binary collimation (iABC) is a novel treatment technique in which dynamic conformal arcs are periodically interrupted with binary collimation. It has demonstrated its utility through planning studies for the treatment of multiple metastases. However, the binary collimation approach is idealized in the planning system, while the treatment deliveries must adhere to the physical limitations of the mechanical systems involved [e.
View Article and Find Full Text PDF"Beyond the Knife"-Applying Theranostic Technologies to Enhance Outcomes in Neurosurgical Oncology.
Brain Sci
December 2024
Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
The current standard of care for brain tumor management includes maximal safe surgical resection followed by concurrent chemotherapy and radiation therapy. Recent advances in image-guided surgical techniques have enhanced the precision of tumor resections, yet there remains a critical need for innovative technologies to further improve patient outcomes. Techniques such as fluorescence image-guided neurosurgery in combination with stereotactic radiosurgery have improved outcomes for patients with brain tumors.
View Article and Find Full Text PDFImpact of MLC error on dose distribution in SRS treatment of single-isocenter multiple brain metastases: comparison between DCAT and VMAT techniques.
Rep Pract Oncol Radiother
December 2024
Department of Radiation Oncology, Kagawa University Hospital, Kagawa, Japan.
Article Synopsis
- Dynamic conformal arc therapy (DCAT) and volumetric modulated arc therapy (VMAT) both provide similar quality for treating brain metastases, but this study focused on how MLC errors during treatment affect dose distribution.
- Researchers created reference plans and simulated MLC errors using a head phantom, analyzing how these errors influenced dose delivery to the targets and surrounding brain tissue.
- The findings revealed that while MLC errors affected both techniques' dose distribution similarly, the DCAT technique showed greater resilience, with less variation in target doses compared to VMAT.
Patient Perspectives on the Value of Stereotactic Body Radiotherapy in the Management of Breast Cancer: The PERSPECTIVE Study.
Clin Oncol (R Coll Radiol)
December 2024
Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK; Department of Radiotherapy, The Royal Marsden NHS Foundation Trust, London, UK.
Aims: Oligometastatic disease describes limited metastases amenable to therapy such as stereotactic body radiotherapy (SBRT). This study aims to understand which outcomes are most important to patients when considering SBRT as a treatment option. The insights gained will help inform future patient-directed trial endpoints and provide valuable guidance to clinicians supporting patients through their decision-making process.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!