Five new diterpene glycosides, virescenosides Z4-Z8 (1-5) have been isolated from a marine strain of Acremonium striatisporum KMM 4401 associated with the holothurian Eupentacta fraudatrix. Their structures were determined by HRESI-MS and 1D and 2D NMR. Virescenosides Z4-Z8 contain rare altruronic acid 4C1 and 1C4 conformations as their carbohydrate components. Virescenosides Z5 and Z7 exhibit an unusual 16-chloro, 15-hydroxyethylgroup as their side chains.
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Metabolite profiles of Paragliomastix luzulae (formerly named as Acremonium striatisporum) KMM 4401 and its co-cultures with Penicillium hispanicum KMM 4689.
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Affiliation G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, 690022 Vladivostok, Russia.
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Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Vladivostok 22, Russian Federation.
Three new diterpene glycosides, virescenosides V (1), W (2), and X (3) have been isolated from a marine strain of Acremonium striatisporum KMM 4401 associated with the holothurian Eupentacta fraudatrix. Their structures have been elucidated on the basis of high resolution mass spectrometry, 1D and 2D NMR (1H, 13C, DEPT, COSY 45, COSY RCT, HSQC, HMBC, and NOESY spectra) as 19-O-beta-D-altropyranosyl-7-oxo-isopimara-8(14),15-diene-2alpha,3beta-diol (1), 19-O-beta-D-altropyranosyl-isopimara-7,15-diene-2 alpha,3 beta,6 alpha-triol (2), and 19-O-beta-D-altropyranosyl-isopimara-8,15-diene-2 alpha,3 beta,7 alpha-triol (3).
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