AI Article Synopsis
- The study examines how peony root extract can reduce the mutagenic effects of benzo[a]pyrene (B[a]p) using the Salmonella typhimurium reversion test.
- Researchers conducted four different experiments to test the extract's impact on both B[a]p and its active metabolites, plus its effects on metabolic processes and mutagenicity activation.
- Results indicated that peony root extract inhibited enzyme activity in the S9 mix and decreased the effectiveness of B[a]p metabolites, showcasing its potential bio-antimutagenic properties.
Article Abstract
The inhibitory effects of peony root extract on the mutagenicity of benzo[a]pyrene (B [a]p) have been investigated in the Salmonella typhimurium reversion test. Four kinds of experiments were performed: direct chemical reaction (1) between peony root extract and B [a]p, and (2) between peony root extract and active metabolite(s) of B [a]p, (3) inhibition of metabolic processes of B[a]p with S9 mix, and (4) inhibition of activation on mutagenicity. Peony root extract interfered with the action of enzymes in the S9 mix, and inactivated the activity of B[a]p metabolites. The bio-antimutagenic effect was assayed by reversion in Salmonella typhimurium TA98 and TA100.
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