Metabolomics and its application to studying metal toxicity.

Metallomics

Department of Biological Sciences, Faculty of Science, University of Calgary, Calgary, Alberta, Canada.

Published: November 2011

Here we explain the omics approach of metabolomics and how it can be applied to study a physiological response to toxic metal exposure. This review aims to educate the metallomics field to the tool of metabolomics. Metabolomics is becoming an increasingly used tool to compare natural and challenged states of various organisms, from disease states in humans to toxin exposure to environmental systems. This approach is key to understanding and identifying the cellular or biochemical targets of metals and the underlying physiological response. Metabolomics steps are described and overviews of its application to metal toxicity to organisms are given. As this approach is very new there are yet only a small number of total studies and therefore only a brief overview of some metal metabolomics studies is described. A frank critical evaluation of the approach is given to provide newcomers to the method a clear idea of the challenges and the rewards of applying metabolomics to their research.

Download full-text PDF

Source
http://dx.doi.org/10.1039/c1mt00070eDOI Listing

Publication Analysis

Top Keywords

metal toxicity
8
physiological response
8
metabolomics
7
metabolomics application
4
application studying
4
metal
4
studying metal
4
toxicity explain
4
explain omics
4
approach
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!