An efficient method for enantioselective synthesis of β-nitrophosphonates via the Michael addition of diphenyl phosphite to nitroalkenes using the readily available quinidine thiourea organocatalyst has been developed. The desired β-nitrophosphonates were obtained in good ee values. Molecular sieves were found to be crucial for achieving high reproducible yields in this reaction.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171176 | PMC |
| http://dx.doi.org/10.1016/j.tet.2011.07.059 | DOI Listing |
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