Objective: Abdominal aortic aneurysm (AAA) is characterized by widening of the aorta. Once the aneurysm exceeds 5.5 cm, there is a 10% risk of death due to rupture. AAA is also associated with mortality due to other cardiovascular disease. Our aim was to investigate clot structure in AAA and its relationship to aneurysm size.
Methods And Results: Plasma was obtained from 49 controls, 40 patients with small AAA, and 42 patients with large AAA. Clot formation was studied by turbidity, fibrin pore structure by permeation, and time to half lysis by turbidity with tissue plasminogen activator. Plasma clot pore size showed a stepwise reduction from controls to small to large AAA. Lag phase for plasma clot formation and time to half lysis were prolonged, with smaller AAA samples showing intermediate response. Clot structure was normal in clots made with fibrinogen purified from patients compared with controls, suggesting a role for other plasma factors. Endogenous thrombin potential and turbidity using tissue factor indicated that the effects were independent of changes in thrombin generation.
Conclusions: Patients with AAA form denser, smaller pored plasma clots that are more resistant to fibrinolysis, and these characteristics correlate with aneurysm size. Clot structure may play a role in AAA development and concomitant cardiovascular disease.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1161/ATVBAHA.111.236786 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prevalence Estimation of Dysfibrinogenemia Using the Clauss-CWA Approach.
Int J Lab Hematol
December 2024
Department of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan.
Introduction: The actual prevalence of the qualitative fibrinogen abnormalities dysfibrinogenemia and hypodysfibrinogenemia is unknown. The major reasons are that patients with dysfibrinogenemia are frequently asymptomatic, and a recommended screening test, the Clauss fibrinogen assay, cannot completely distinguish qualitative from quantitative abnormalities. We previously established a high-throughput screening test (Clauss-CWA) to identify dysfibrinogenemia with high specificity and sensitivity by the Clauss fibrinogen assay alone.
View Article and Find Full Text PDFDependence of clot structure and fibrinolysis on apixaban and clotting activator.
Res Pract Thromb Haemost
November 2024
Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey, USA.
Background: Anticoagulants prevent the formation of potentially fatal blood clots. Apixaban is a direct oral anticoagulant that inhibits factor (F)Xa, thereby impeding the conversion of prothrombin into thrombin and the formation of blood clots. Blood clots are held together by fibrin networks that must be broken down (fibrinolysis) to restore blood flow.
View Article and Find Full Text PDFThe Efficacy of Collagen Barrier Membranes in Regenerating Vertical Bone Defects: A Clinical and Cone Beam Computed Tomography (CBCT) Assessment.
Cureus
October 2024
Department of Periodontology and Dental Implantology, Medical University of Varna, Varna, BGR.
Context The underlying principle of guided tissue regeneration (GTR) lies in the use of barrier membranes. Their role is key to this method, as they inhibit the rapid growth of epithelial and connective tissue cells, thus isolating the infrabony defects (IBDs) and ensuring the regeneration of slower-growing periodontal structures. The main disadvantages of resorbable membranes are related to their limited time of action and the need to use them in two layers, which increases the chance of a postoperative complication, i.
View Article and Find Full Text PDFGene expression analysis of cytokines and MMPs in melatonin and rhBMP-2 enhanced bone remodeling.
World J Orthop
November 2024
Department of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo, Ribeirao Preto 14040-904, Brazil.
Article Synopsis
- The study explores new treatments for extensive bone loss, focusing on the potential of melatonin and growth factors in bone remodeling and repair.
- Researchers evaluated how various concentrations of melatonin and rhBMP-2 influence the expression of bone-related cytokines and markers in rats with bone injuries.
- Results indicate that higher concentrations of melatonin combined with rhBMP-2 showed some improvements in bone repair, suggesting a need for better application methods in future research.
Ultrasound-mediated catheter delivery of tissue plasminogen activator promotes thrombolysis by altering fibrin fibre thickness and clot permeability.
Haematologica
November 2024
Leeds Thrombosis Collective, Discovery and Translational Science Department, Leeds Institute of Cardiovascular And Metabolic Medicine, University of Leeds, Leeds.
It has been proposed that low power, high frequency ultrasound can augment the ability of thrombolytic agents to dissolve clot in patients with venous thromboembolism. We created a bench model to examine what role and mechanism ultrasound may have in this process. Fibrin polymerisation was analysed through modified light-scattering experiments with the inclusion of catheter-mediated ultrasound application.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!