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Intratumor heterogeneity of HPV integration in HPV-associated head and neck cancer.
Nat Commun
January 2025
Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Integration of human papillomavirus (HPV) into the host genome drives HPV-positive head and neck squamous cell carcinoma (HPV HNSCC). Whole-genome sequencing of 51 tumors revealed intratumor heterogeneity of HPV integration, with 44% of breakpoints subclonal, and a biased distribution of integration breakpoints across the HPV genome. Four HPV physical states were identified, with at least 49% of tumors progressing without integration.
View Article and Find Full Text PDFEpigenetic alteration in cervical cancer induced by human papillomavirus.
Int Rev Cell Mol Biol
January 2025
Posgrado en Ciencias Genómicas, Laboratorio de Patogenesis Celular y Molecular Humana y Veterinaria, Universidad Autónoma de la Ciudad de México, Ciudad de México, México. Electronic address:
The critical role of a subset of Human Papillomavirus in cervical cancer has been widely acknowledged and studied. Despite progress in our understanding of the viral molecular mechanisms of pathogenesis, knowledge of how infection with HPV oncogenic variants progresses from latent infection to incurable cancer has not been completely elucidated. In this paper we reviewed the relationship between HPV infection and epigenetic mechanisms such as histone acetylation and deacetylation, DNA methylation and non-coding RNAs associated with this infection and the carcinogenic process.
View Article and Find Full Text PDFAssociation of Epstein-Barr Virus and its clinical relevance in Human Papillomavirus-negative oral squamous cell carcinoma: A cohort study from South India.
Arch Oral Biol
January 2025
Department of Microbiology, KS Hegde Medical Academy, Nitte (Deemed to be University), Deralakatte, Mangaluru 575018, India. Electronic address:
Objective: The study assessed the prevalence and clinical implications of Epstein Barr Virus (EBV)-positive but Human Papillomavirus (HPV)-negative oral squamous cell carcinoma (OSCC) in a tertiary care hospital setting. The overall goal was to elucidate the potential impact of EBV on OSCC disease progression and prognosis.
Design: A total of 134 surgically resected and histopathologically confirmed OSCC tumor biopsies were collected from a tertiary care hospital.
The association between adolescents' knowledge and perception of HPV vaccination and parents' characteristics: A cross-sectional study.
Appl Nurs Res
February 2025
Interdisciplinary Department of Medicine, "Aldo Moro" University of Bari, Bari, Italy. Electronic address:
Background: In Italy, the anti-Human Papillomavirus (HPV) vaccination campaign began in 2008. To date, despite the effectiveness and safety of HPV vaccines, coverage among Italian adolescents is still suboptimal. Evidence suggests that different factors could influence parents' choices regarding their children's vaccination uptake.
View Article and Find Full Text PDFInvestigating the role of lifestyle, knowledge and health beliefs in performing preventive behaviours against human papilloma virus in married women.
Appl Nurs Res
February 2025
Department of Health Education and Health Promotion, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.
Objectives: The aim of this research was investigating the role of lifestyle, knowledge and health beliefs in performing preventive behaviours against HPV in married women.
Background: Human Papilloma Virus (HPV) is a significant public health concern in Iran, with a relatively high prevalence in the general female population.
Methods: The study utilized a cross-sectional survey among 260 married women working at the university.
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