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| http://dx.doi.org/10.1113/jphysiol.2011.216572 | DOI Listing |
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A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, 690041 Vladivostok, Russia.
The ultrastructural organization of the nuclei of the tegmental region in juvenile chum salmon () was examined using transmission electron microscopy (TEM). The dorsal tegmental nuclei (DTN), the nucleus of (NFLM), and the nucleus of the oculomotor nerve (NIII) were studied. The ultrastructural examination provided detailed ultrastructural characteristics of neurons forming the tegmental nuclei and showed neuro-glial relationships in them.
View Article and Find Full Text PDFDendritic pathology and overexpression of MAP2 in Purkinje cells from mice inoculated with rabies virus.
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Grupo de Morfología Celular, Instituto Nacional de Salud (INS), Av. Calle 26 No. 51-20, Bogotá, DC, 111321, Colombia.
The effect of rabies virus infection on dendritic morphology and on the expression of the MAP2 protein in Purkinje cells in the cerebellum of mice was studied. ICR mice were inoculated with rabies virus, and six days later, the mice were sacrificed, the cerebellum was removed and processed for Golgi-Cox staining or MAP2 immunohistochemistry. Infection with rabies virus altered the dendritic pattern of Purkinje cells ranged from moderate changes to accentuated retraction in the dendritic tree of some Purkinje cells.
View Article and Find Full Text PDFGlyT2-positive interneurons regulate timing and variability of information transfer in a cerebellar-behavioural loop.
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School of Physiology Pharmacology and Neuroscience, University of Bristol, University Walk, Bristol, UK. BS8 1TD.
GlyT2-positive interneurons, Golgi and Lugaro cells, reside in the input layer of the cerebellar cortex in a key position to influence information processing. Here, we examine the contribution of GlyT2-positive interneurons to network dynamics in Crus 1 of mouse lateral cerebellar cortex during free whisking. We recorded neuronal population activity using NeuroPixels probes before and after chemogenetic downregulation of GlyT2-positive interneurons in male and female mice.
View Article and Find Full Text PDFA dominant negative Kcnd3 F227del mutation in mice causes spinocerebellar ataxia type 22 (SCA22) by impairing ER and Golgi functioning.
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Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.
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View Article and Find Full Text PDFCornelia de Lange Syndrome: Expanding the Neuropathological Spectrum and Clinical Correlations.
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Pathologic Anatomy Section, Maternal-Pediatric and Adult Department of Clinical and Surgical Sciences, University of Modena & Reggio Emilia (UNIMORE), Modena, Italy.
Article Synopsis
- * Key findings include significant brain abnormalities such as diffuse hypoplasia, nerve cell heterotopies, and immature nerve cells in cerebellar tissue from a newborn affected by the syndrome.
- * These findings highlight the relevance of Cornelia de Lange syndrome as a cohesinopathy and open up discussions on its impact on global intellectual disability in affected patients.
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