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The potential of plasma-activated water in safe and sustainable food production: a comprehensive review of recent advances and future trends.
Crit Rev Food Sci Nutr
March 2025
College of Engineering, China Agricultural University, Beijing, China.
Climate change and food security issues have increased the demand for effective and sustainable technologies in the food and agriculture sectors. Plasma-activated water (PAW), a novel cleaning and disinfecting agent enriched with reactive oxygen species and reactive nitrogen species, has attracted widespread attention due to its potential application in maintaining microbiological safety and other quality parameters of food products. Compared to traditional disinfection methods, PAW is rapid and effective for various products, unrestricted by the volume or shape of the treated sample, and is green and sustainable.
View Article and Find Full Text PDFBiosilicification-mimicking chiral nanostructures for targeted treatment of inflammatory bowel disease.
Nat Commun
March 2025
School of Pharmacy, China Medical University, Shenyang, China.
The cascade reaction of lipopolysaccharides (LPS), cell-free DNA (cfDNA), and reactive oxygen species (ROS), drives the development of inflammatory bowel disease (IBD). Herein, we construct polyethylenimide (PEI)-L/D-tartaric acid (L/D-TA) complexes templated mesoporous organosilica nanoparticles (MON) (PEI-L/D-TA@MON) by mimicking biosilicification under ambient conditions within seconds. The chiral nanomedicines include four functional moieties, wherein PEI electrostatically attracts cfDNA, tetrathulfide bonds reductively react with ROS, silanol groups adsorb LPS, and L/D-TA enables chiral recognition and inflammatory localization.
View Article and Find Full Text PDFThe rheumatoid arthritis drug Auranofin targets peroxiredoxin 1 and peroxiredoxin 2 to trigger ROS-endoplasmic reticulum stress axis-mediated cell death and cytoprotective autophagy.
Free Radic Biol Med
March 2025
Center for Drug Research and Development, Guangdong Provincial Key Laboratory for Research and Evaluation of Pharmaceutical Preparations, Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong, China. Electronic address:
Auranofin (AF) is a gold-based compound and it has been used in the treatment of rheumatoid arthritis for over four decades. Recently, it has been demonstrated to show significant antitumor activity across various cancer types and is being repurposed as an anticancer drug. However, the precise mechanisms underlying its antitumor effects, particularly its binding targets, remain poorly understood.
View Article and Find Full Text PDFAddressing NHS chemistry: Efficient quenching of excess TMT reagent and reversing TMT-over labelling in proteomic samples by methylamine.
Mol Cell Proteomics
March 2025
The Rosalind Franklin Institute, Harwell, UK; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK; Department of Biochemistry, University of Oxford, Oxford, UK. Electronic address:
N-Hydroxysuccinimide (NHS) ester chemistry is used extensively across proteomics sample preparation. One of its increasingly prevalent applications is in isobaric reagent-based quantitation such as iTRAQ (isobaric tags for relative and absolute quantitation) and TMT (tandem mass tag) approaches. In these methods, labelling on the primary amines of lysine residues and N-termini of tryptic peptides via amide formation (N-derivatives) from corresponding NHS ester reagents is the intended reactive outcome.
View Article and Find Full Text PDFLiposomal formulation co-encapsulating α-tocopheryl succinate and α-tocopherol ameliorates high-fat diet-induced obesity.
J Pharm Sci
March 2025
Department of Pharmaceutical Health Chemistry, Graduate School of Biomedical Sciences, Tokushima University, 1-78-1 Shomachi, Tokushima, 770-8505, Japan; Research Center for Innovative Drug Delivery System, Graduate School of Biomedical Sciences, Tokushima University, 1-78-1 Shomachi, Tokushima, 770-8505, Japan. Electronic address:
Lipid accumulation inhibition is a pivotal focus for anti-obesity drugs. α-Tocopheryl succinate (TS) is a derivative of α-tocopherol (T) that inhibits lipid accumulation, making it a propitious candidate for an anti-obesity agent. However, cytotoxicity of TS limits its application.
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