PGP, as well as GPGPGP remain stable after 24-hour incubation in a proteolytic environment (in vitro), like equine and rat gastric juice, hydrochloric acid and pepsin in the solution of hydrochloric acid. Perhaps the appearance of PGP's metabolites--PG and GP, that found in the stomachic tissues, is associated with the action of tissue and blood peptidases. Thus, the effects of PGP and GPGPGP cause by the influences both of the peptides and their metabolites, that agree with previously results.
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Eksp Klin Gastroenterol
October 2011
Bull Exp Biol Med
August 2007
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University.
Glyprolines (PGP, GPG, GPGP, PGPGP, and GPGPGP) modulated histomorphological characteristics of acetate ulcers. They accelerated healing of acetate ulcers, promote complete differentiation of the surface epithelium and glands in the gastric mucosa, contributed to the appearance of a considerable number of fibroblasts at the site of the regenerating mucosa, and significantly decreased the count of macrophages.
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