AI Article Synopsis

  • PGP and GPGPGP are stable for 24 hours in proteolytic environments, such as equine and rat gastric juices, indicating their resilience in acidic conditions.
  • The metabolites of PGP—PG and GP—may be linked to the actions of peptidases in tissue and blood, suggesting that these enzymes play a role in their breakdown.
  • The effects of PGP and GPGPGP seem to stem from both the peptides themselves and their metabolites, supporting earlier research findings.

Article Abstract

PGP, as well as GPGPGP remain stable after 24-hour incubation in a proteolytic environment (in vitro), like equine and rat gastric juice, hydrochloric acid and pepsin in the solution of hydrochloric acid. Perhaps the appearance of PGP's metabolites--PG and GP, that found in the stomachic tissues, is associated with the action of tissue and blood peptidases. Thus, the effects of PGP and GPGPGP cause by the influences both of the peptides and their metabolites, that agree with previously results.

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Article Synopsis
  • PGP and GPGPGP are stable for 24 hours in proteolytic environments, such as equine and rat gastric juices, indicating their resilience in acidic conditions.
  • The metabolites of PGP—PG and GP—may be linked to the actions of peptidases in tissue and blood, suggesting that these enzymes play a role in their breakdown.
  • The effects of PGP and GPGPGP seem to stem from both the peptides themselves and their metabolites, supporting earlier research findings.
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Glyprolines (PGP, GPG, GPGP, PGPGP, and GPGPGP) modulated histomorphological characteristics of acetate ulcers. They accelerated healing of acetate ulcers, promote complete differentiation of the surface epithelium and glands in the gastric mucosa, contributed to the appearance of a considerable number of fibroblasts at the site of the regenerating mucosa, and significantly decreased the count of macrophages.

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