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Biomarkers.
Alzheimers Dement
December 2024
Memory Clinic, Department of Neurology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.
Background: Synaptic dysfunction occurs in the early stages of neurodegenerative diseases and leads to the breakdown of connections within neuronal networks. Therefore, biomarkers reflecting this process, such as neurogranin (Ng), might be useful to study disease pathophysiology and aid in diagnostics. Ng is crucial for long-term potentiation and memory consolidation, and plays a central role in synaptic plasticity.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands.
Background: Co-pathology between Alzheimer's disease (AD), Parkinson's disease (PD), and dementia with Lewy bodies (DLB) remains poorly understood but is relevant for trial design. We aimed to compare CSF markers of amyloid, tau, and neurodegeneration (ATN) and α-synuclein between AD, PD, DLB and controls, and investigate the influence of demographical, genetic, and clinical factors on amyloid positivity.
Method: As part of the EPND study, we included 337 individuals with AD, PD, DLB and controls from 6 centers.
Cross-sectional analysis of risk factors associated with the coexistence of three undernutrition indicators among children aged 0-23 months in Tanzania.
BMC Nutr
January 2025
Department of Statistics, University of Dar Es Salaam, P.O.BOX 35047, Dar Es Salaam, Tanzania.
Background: Undernutrition in children under two years is a persistent challenge in Tanzania. This study investigates demographic, maternal, and child-related factors associated with stunting, wasting, and underweight coexistence.
Methods: Secondary data from 2,158 children aged 0-23 months in the 2022 Tanzania Demographic and Health Survey (TDHS) were analyzed.
Optimizing Home Visit Records as a Way of Improving Quality of Care: A Quality Improvement Study.
Cureus
December 2024
Family Medicine, Unidade de Saúde Familiar (USF) Vil'Alva, Unidade Local de Saúde do Médio Ave, Santo Tirso, PRT.
Introduction Home visits are a key component of primary care in Portugal, designed for patients unable to visit medical facilities. However, logistical constraints often lead to incomplete real-time clinical records, impacting care quality and safety. This study aimed to improve the quality of home visit records through structural interventions and a continuous quality improvement approach.
View Article and Find Full Text PDFEpidemiology and clinical features of childhood malignant solid tumors in a single center in southwest China over 24 years.
BMC Pediatr
January 2025
Department of Urology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, No. 136, Zhongshan 2nd Road, Yuzhong District, Chongqing, 400014, P.R. China.
Objective: This study aims to analyze the epidemiological characteristics and clinical features of childhood malignant solid tumors in a single center in southwest China, thereby providing a reliable basis for formulating prevention and control strategies and rational allocation of resources for these tumors.
Methods: Children less than 15 years old and under-diagnosed with malignant solid tumors for the first time at Children's Hospital of Chongqing Medical University (Children's Medical Center of Southwest China) from 2000 to 2023 were selected. They were classified according to the International Classification of Childhood Cancer, Third Edition (ICCC-3).
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