Background: The objective of this study was to establish temporal stability characteristics for objective components of the Unified Dyskinesia Rating Scale (UDysRS). The UDysRS has strong internal consistency and a reliable factor structure, but the important issue of temporal stability has not been established.
Methods: Using intraclass correlation coefficient (ICC) analyses, we examined UDysRS temporal stability for the objective scale components (Part III and IV) over an 8-hour observation period. We assessed ICCs for the single centralized rater, the on-site raters, and the agreement between the single centralized rater and the on-site raters. Kappa statistic assessed agreement between the single centralized and on-site raters for clinical state (ON vs OFF).
Results: For both the single centralized rater and the on-site raters, there was high temporal stability of the UDysRS Part III, Part IV, and Total Objective UDysRS in both ON and OFF states, with ICCs ranging from 0.822 (P < .0005) to 0.513 (P < .013). The agreement between the 2 rating techniques (centralized vs on-site) was significant for ON and OFF ratings of Part III, Part IV, and Total Objective UDysRS, ranging from 0.821 (P < .0005) to 0.703 (P < .0005).
Conclusions: The UDysRS is highly stable for ON and OFF. Our data suggest that a single UDysRS evaluation for ON and for OFF states is highly representative of that state regardless of time. Likewise, if appropriate protocols need to assess dyskinesia in a field or community setting, the UDysRS can be filmed without an on-site rater and rated centrally with retained validity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/mds.23931 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
University of Pennsylvania, Philadelphia, PA, USA.
Background: Historically underrepresented populations experience a disproportionate burden of Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD) compared to White populations. As a salient resource for coping in Black communities, spiritual and religious practice may support better cognitive health, but it is unknown if changes in these practices are related to cognitive decline.
Methods: We analyzed secondary data of cognitively normal (via Consensus Conference at enrollment) older adults in the U.
Psychometric analysis of the three item loneliness scale in the Czech Republic.
BMC Psychol
January 2025
Olomouc University Social Health Institute, Palacký University Olomouc, Univerzitni 244/22, Olomouc, 771 11, Czech Republic.
Background: There is a growing importance of loneliness measurement through valid and reliable instruments. However, to establish valid and reliable measures, there is a need to explore their psychometric properties in different research settings and language environments. For this reason, this study aimed to validate the Three Item Loneliness Scale (TILS) in the Czech Republic within a Slavonic language environment.
View Article and Find Full Text PDFSubgroups of cognitive impairments in schizophrenia characterized by executive function and their morphological features: a latent profile analysis study.
BMC Med
January 2025
Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Background: The heterogeneity of cognitive impairments in schizophrenia has been widely observed. However, reliable cognitive boundaries to differentiate the subgroups remain elusive. The key challenge for cognitive subtyping is applying an integrated and standardized cognitive assessment and understanding the subgroup-specific neurobiological mechanisms.
View Article and Find Full Text PDFReactivation and consolidation of memory traces during post-encoding rest across the adult lifespan.
Ann Clin Transl Neurol
January 2025
Department of Psychology, Binghamton University, Binghamton, New York, 13902, USA.
Episodic memory is a critical cognitive function that enables the encoding, storage, and retrieval of new information. Memory consolidation, a key stage of episodic memory, stabilizes this newly encoded information into long-lasting brain "storage." Studies using fMRI to investigate post-encoding awake rest holds promise to shed light on early, immediate consolidation mechanisms.
View Article and Find Full Text PDFPosttranscriptional Control of Neural Progenitors Temporal Dynamics During Neocortical Development by Syncrip.
Adv Sci (Weinh)
January 2025
State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry & Molecular Biology, Medical Primate Research Center, Neuroscience Center, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, 100005, China.
The development of the mammalian neocortex is precisely regulated by temporal gene expression, yet the temporal regulatory mechanisms of cortical neurogenesis, particularly how radial glial cells (RGCs) sequentially generate deep to superficial neurons, remain unclear. Here, the hnRNP family member Syncrip (hnRNP Q) is identified as a key modulator of superficial neuronal differentiation in neocortical neurogenesis. Syncrip knockout in RGCs disrupts differentiation and abnormal neuronal localization, ultimately resulting in superficial cortical layer defects as well as learning and memory impairments in mice.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!