The synthesis of new, artificial ribonucleases containing two amino acid residues connected by an aliphatic linker has been developed. Target molecules were synthesized via a catalytic three-component Ugi reaction from aliphatic diisocyanides. Preliminary investigations proved unspecific nuclease activity of the new compounds towards single-stranded RNA and double-stranded circular DNA.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170195 | PMC |
| http://dx.doi.org/10.3762/bjoc.7.131 | DOI Listing |
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