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Updates in Prostate Cancer Research and Screening in Men at Genetically Higher Risk.
Curr Genet Med Rep
October 2021
Urology Genetics, The Royal Marsden NHS Foundation Trust, Downs Road, Sutton, SM2 5PT, UK.
Article Synopsis
- - Prostate cancer is the most common cancer among men in the western world, but general screening isn't recommended due to limitations of the PSA test; focus is shifting toward identifying and screening higher-risk groups based on age, ethnicity, and family history.
- - Recent studies have found rare genetic variants that increase the risk of prostate cancer and are investigating the use of a "polygenic risk score" (PRS) to personalize screening for these men, with a particular focus on at-risk groups like Black Afro-Caribbean men.
- - Integrating genomics into prostate cancer screening and treatment is becoming standard practice, enhancing the potential for targeted therapies and better outcomes for men with genetic predispositions to the disease.
Prostate cancer screening-when to start and how to screen?
Transl Androl Urol
February 2018
Institute of Clinical Sciences, Department of Urology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Prostate-specific antigen (PSA) screening reduces prostate cancer (PCa) mortality; however such screening may lead to harm in terms of overdiagnosis and overtreatment. Therefore, upfront shared decision making involving a discussion about pros and cons between a physician and a patient is crucial. Total PSA remains the most commonly used screening tool and is a strong predictor of future life-threatening PCa.
View Article and Find Full Text PDFFailed triple therapy in a treatment-experienced patient with genotype 6 hepatitis C infection.
Am J Health Syst Pharm
February 2014
Roseann S. Gammal, Pharm.D., is Postgraduate Year 1 Pharmacy Practice Resident, Department of Pharmacy, University of North Carolina Hospitals and Clinics, Chapel Hill. Linda M. Spooner, Pharm.D., BCPS, is Associate Professor of Pharmacy Practice, School of Pharmacy, MCPHS University, Worcester, MA. George M. Abraham, M.D., M.P.H., is Professor of Medicine, University of Massachusetts Medical School, Worcester, and Associate Chief of Medicine, Division of Infectious Disease and Geographic Medicine, Saint Vincent Hospital, Worcester.
Purpose: The first published report of the use of triple therapy in a patient with hepatitis C virus (HCV) genotype 6 infection-a treatment that was prescribed due to incorrect HCV genotyping and which ultimately failed-is presented.
Summary: A 70-year-old male U.S.
The descent of a man's testosterone.
Proc Natl Acad Sci U S A
September 2011
Department of Anthropology, University of Nevada, Las Vegas, NV 89154, USA.
An efficient multiplex genotyping approach for detecting the major worldwide human Y-chromosome haplogroups.
Int J Legal Med
November 2011
Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
The Y chromosome is paternally inherited and therefore serves as an evolutionary marker of patrilineal descent. Worldwide DNA variation within the non-recombining portion of the Y chromosome can be represented as a monophyletic phylogenetic tree in which the branches (haplogroups) are defined by at least one SNP. Previous human population genetics research has produced a wealth of knowledge about the worldwide distribution of Y-SNP haplogroups.
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