The present review focuses on the interaction of microgels and microcapsules with biological macromolecules, particularly peptides and proteins, as well as drug delivery applications of such systems. Results from recent studies on factors affecting peptide/protein binding to, and release from, microgels and related systems are discussed, including effects of network properties, as well as protein aggregation, peptide length, hydrophobicity and charge (distributions), secondary structure, and cyclization. Effects of ambient conditions (pH, ionic strength, temperature, etc.) are also discussed, all with focus on factors of importance for the performance of microgel and microcapsule delivery systems for biomacromolecular drugs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.addr.2011.08.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Viability and stability evaluation of microencapsulated Lactobacillus reuteri in polysaccharide-based bionanocomposite.
Carbohydr Polym
January 2025
Biotechnology Group, Faculty of Chemical Engineering, Tarbiat Modares University, Tehran, Iran. Electronic address:
Microencapsulation is one of the most important methods to enhance the survival of bacteria when exposed to various harsh conditions. The present study evaluated the viability of L. reuteri ATCC 23272 microencapsulated in polysaccharide-based bionanocomposite.
View Article and Find Full Text PDFBioactive compounds delivery and bioavailability in structured edible oils systems.
Compr Rev Food Sci Food Saf
November 2024
Food Engineering Department, Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Cluj-Napoca, Romania.
The health benefits of bioactive compounds are dependent on the amount of intake as well as on the amount of these compounds that become bioavailable and bioaccessible. Various systems have been developed to deliver and increase the bioaccessibility of bioactive compounds. This review explores the impact of gelled (oleogels, bigels, emulgels, emulsions, hydrogels, and hydrogel beads), micro-(gels, particles, spheres, capsules, emulsions, and solid lipid microparticles) and nanoencapsulated systems (nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, nanoemulsions, liposomes, and nanoliposomes) on the digestibility and bioavailability of lipophilic and hydrophilic bioactives.
View Article and Find Full Text PDFDroplet Microfluidics for High-Throughput Screening and Directed Evolution of Biomolecules.
Micromachines (Basel)
July 2024
Department of Chemical Engineering, Loughborough University, Loughborough LE11 3TU, UK.
Directed evolution is a powerful technique for creating biomolecules such as proteins and nucleic acids with tailor-made properties for therapeutic and industrial applications by mimicking the natural evolution processes in the laboratory. Droplet microfluidics improved classical directed evolution by enabling time-consuming and laborious steps in this iterative process to be performed within monodispersed droplets in a highly controlled and automated manner. Droplet microfluidic chips can generate, manipulate, and sort individual droplets at kilohertz rates in a user-defined microchannel geometry, allowing new strategies for high-throughput screening and evolution of biomolecules.
View Article and Find Full Text PDFUpscaling Osteoclast Generation by Enhancing Macrophage Aggregation Using Hollow Microgels.
Small
November 2024
Regenerative Biomaterials, Department of Dentistry, Radboudumc, Philips van Leydenlaan 25, Nijmegen, 6525EX, The Netherlands.
Osteoclasts, the bone resorbing cells of hematopoietic origin formed by macrophage fusion, are essential in bone health and disease. However, in vitro research on osteoclasts remains challenging due to heterogeneous cultures that only contain a few multinucleated osteoclasts. Indeed, a strategy to generate homogeneous populations of multinucleated osteoclasts in a scalable manner has remained elusive.
View Article and Find Full Text PDFIonic Polymerization-Based Synthesis of Bioinspired Adhesive Hydrogel Microparticles with Tunable Morphologies from Microfluidics.
ACS Appl Mater Interfaces
July 2024
The State Key Laboratory of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, P. R. China.
Shape-anisotropic hydrogel microparticles have attracted considerable attention for drug-delivery applications. Particularly, nonspherical hydrogel microcarriers with enhanced adhesive and circulatory abilities have demonstrated value in gastrointestinal drug administration. Herein, inspired by the structures of natural suckers, we demonstrate an ionic polymerization-based production of calcium (Ca)-alginate microparticles with tunable shapes from Janus emulsion for the first time.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!