Purpose: To assess the retinal ganglion cells function in patients with ocular hypertension (OHT).
Material And Methods: In one hundred eyes of 50 patients with ocular hypertension [mean age: 48 +/- 13 years, intraocular pressure mean: 26 +/- 3.0 mmHg; Humphrey Field Analyzer (HFA) 24-2 W-W mean deviation (MD) > -2 decibels (dB), normal optic nerve fiber layer results in scanning laser polarimetry (GDX)], PERG recordings were performed according to the modified methodology described by Parisi V et al. (Ophthalmology 2006; 113: 216-228). Main parameters measured in the PERG test were as follows: amplitude of the P50 and N95 waves, AN95/AP50 ratio as well as implicit time of P50 wave. Pattern Electroretinogram P50 implicit times were considered delayed when exceeding the limit of mean values plus 2 standard deviations (SDs) from controls. PERG amplitudes of P50, N95 waves and AN95/AP50 ratio were considered reduced when they were below the mean values minus 2 SDs from controls. Control group consisted of age, sex, and refractive error matched one hundred eyes of 50 healthy subjects with intraocular pressure mean equal to 16 +/- 4.0 mmHg.
Results: In the OHT eyes, significant reductions of AN95-wave (p < 0.0002) and AN95/AP50 ratio (p < 0.002) were obtained in comparison to controls. The PERG test revealed the abnormalities mostly in AN95/AP50 ratio (32/100 of OHT eyes--32%). Other less frequent abnormalities were observed in amplitude of N95-wave (10/100 of OHT eyes--10%) and in amplitude of P50-wave (6/100 of OHT eyes--6%). The implicit times of P50 and N95-waves were within normal limits.
Conclusions: In the eyes of the OHT patients, retinal ganglion cells dysfunction is present and can be detected by the PERG test. Longer follow-up is necessary to show predictable value of the PERG examination in separation of the OHT patients with a high risk of glaucoma development.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Comparison of functional, structural and vascular characteristics between dominant and nondominant eyes.
Doc Ophthalmol
December 2024
Department of Ophthalmology, Bilkent City Hospital, Ankara, Turkey.
Purpose: The aim of this study was to compare retinal and optic disc functions as well as vascular structures in dominant eyes (DE) and non-dominant eyes (NDE) among healthy adults using pattern electroretinogram (PERG), optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) tests.
Methods: Seventy-two eyes of 36 healthy subjects with bilateral visual acuity of 1.0 were included.
Purpose: The aim of this study was to test whether oral administration of nicotinamide riboside (NR), the nicotinamide adenine dinucleotide (NAD+) precursors, protect retina ganglion cells (RGCs) from neurodegeneration in DBA/2J (D2) mice, which is a widely used mouse model of age-related inherited glaucoma.
Method: Oral NR or NAM administration (NR low dose: 1150mg/kg; NR high dose: 4200mg/kg; NAM low dose group: 500mg/kg; NAM high dose: 2000mg/kg of body weight per day) essentially started when D2 mice were 4 or 9 months old and continued up to 12 months old. Control cohort identically received food/water without NAM or NR.
A comprehensive dataset of pattern electroretinograms for ocular electrophysiology research.
Sci Data
September 2024
Institute of Applied Ophthalmobiology (IOBA), University of Valladolid, Valladolid, 47011, Spain.
The Pattern Electroretinogram (PERG) is an essential tool in ophthalmic electrophysiology, providing an objective assessment of the central retinal function. It quantifies the activity of cells in the macula and the ganglion cells of the retina, assisting in the differentiation of macular and optic nerve conditions. In this study, we present the IOBA-PERG dataset, an extensive collection of 1354 transient PERG responses accessible on the PhysioNet repository.
View Article and Find Full Text PDFReduced contrast sensitivity, pattern electroretinogram ratio, and diminished a-wave amplitude in patients with major depressive disorder.
Eur Arch Psychiatry Clin Neurosci
May 2024
Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Article Synopsis
- - The study investigates how depression affects visual processing using the electroretinogram (ERG), focusing on patients with major depressive disorder (MDD) and comparing them to healthy controls (HC).
- - Results showed that MDD patients had lower contrast sensitivity and reduced pattern ERG (PERG) ratios, indicating alterations in visual processing linked to depression.
- - The use of a handheld ERG device revealed diminished a-wave amplitudes in MDD patients, highlighting its potential as a practical tool for depression research and suggesting the PERG may serve as an objective marker for the condition.
IC100, a humanized therapeutic monoclonal anti-ASC antibody alleviates oxygen-induced retinopathy in mice.
Angiogenesis
August 2024
Department of Pediatrics/Division of Neonatology, Batchelor Children's Research Institute and Holtz Children's Hospital, University of Miami Miller School of Medicine, P. O. Box 016960, Miami, FL, 33101, USA.
Background: Retinopathy of prematurity (ROP), which often presents with bronchopulmonary dysplasia (BPD), is among the most common morbidities affecting extremely premature infants and is a leading cause of severe vision impairment in children worldwide. Activations of the inflammasome cascade and microglia have been implicated in playing a role in the development of both ROP and BPD. Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is pivotal in inflammasome assembly.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!