Acute toxicity of 1-methyl-3-octylimidazolium bromide ([C(8)mim]Br) to goldfish at different developmental stages and responses of the antioxidant system in adult goldfish were evaluated in the present study. The results indicate that post-embryonic developmental toxicity of [C(8)mim]Br on goldfish is developmental-stage dependent. The juvenile and larva goldfish are more sensitive to [C(8)mim]Br-toxicity than the adult fish. Histological observations in adult goldfish reveal that acute [C(8)mim]Br exposure damages the hepatopancreas, intestines, and kidneys, indicating that these are possible target organs of [C(8)mim]Br toxicity in goldfish. Subsequent biochemical assays in adult goldfish show that [C(8)mim]Br also induces changes in the activities of the superoxide dismutase, catalase, glutathione peroxidase, and glutathione content of fish hepatopancreas. These results suggest that [C(8)mim]Br exposure may induce oxidant stress and lipid peroxidation in hepatopancreas of adult goldfish. In addition, we also find that [C(8)mim]Br causes a remarkable increase in malondialdehyde (MDA) levels in the hepatopancreas of adult goldfish, and thus we think that the MDA level change can be a biomarker of [C(8)mim]Br toxicity in goldfish. The present study indicates that ionic liquids can be a threat to the survival, growth, and development of the fish population once they are accidentally leaked into aquatic ecosystems.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10646-011-0785-zDOI Listing

Publication Analysis

Top Keywords

adult goldfish
20
goldfish
11
acute toxicity
8
responses antioxidant
8
1-methyl-3-octylimidazolium bromide
8
developmental stages
8
[c8mim]br
8
[c8mim]br goldfish
8
[c8mim]br exposure
8
[c8mim]br toxicity
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!