AI Article Synopsis
- Artesuante (AS) is an effective drug for preventing schistosome infections, but recent findings suggest its effectiveness may be declining in China after 10 years of use.
- A report by Hua et al. raises concerns about the emergence of potential resistance in Schistosoma japonicum, but the authors highlight flaws in the study that make its conclusions questionable.
- The authors advocate for more thorough and convincing research to confirm these findings, as the rise of AS-resistant S. japonicum could significantly impact future treatment options.
Article Abstract
Artesuante (AS) is a good chemoprophylactic drug for preventing against schistosome infection, but Hua et al. recently reported that the sensitivity of AS against Schistosoma japonicum decreased after 10 years of use in China. There are at least three problems, to our knowledge, making the finding suspicious or inconclusive in that report. In consideration of it as the first report about the emergence of potential artemisinin derivative-resistant S. japonicum to date and the possible severe influences of the emergence of AS-resistant S. japonicum on the future choice of chemoprophylactic drugs for preventing against S. japonicum infections in China, we write this comment and call for some more rigorous and convincing trials to confirm this finding further.
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| http://dx.doi.org/10.1007/s00436-011-2641-8 | DOI Listing |
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