A synthesis of multifunctional dirhodium metallopeptide ligands for MDM2 is presented. An orthogonal protection scheme of palladium-catalyzed de-allylation on a metallopeptide substrate allows specific dirhodium incorporation in a complex peptide. Sequence effects on MDM2 binding are discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/c1cc13169a | DOI Listing |
Publication Analysis
Top Keywords
general synthesis
4
synthesis dirhodium
4
dirhodium metallopeptides
4
metallopeptides mdm2
4
mdm2 ligands
4
ligands synthesis
4
synthesis multifunctional
4
multifunctional dirhodium
4
dirhodium metallopeptide
4
metallopeptide ligands
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!