In this study of 41 patients, we used proteomic, Western blot and immunohistochemical analyses to show that several reactive oxygen species scavenging enzymes are expressed differentially in patients with primary osteoarthritis and those with non-loosening and aseptic loosening after total hip replacement (THR). The patients were grouped as A (n = 16, primary THR), B (n = 10, fixed THR but requiring revision for polyethylene wear) and C (n = 15, requiring revision due to aseptic loosening) to verify the involvement of the identified targets in aseptic loosening. When compared with Groups A and B, Group C patients exhibited significant up-regulation of transthyretin and superoxide dismutase 3, but down-regulation of glutathione peroxidase 2 in their hip synovial fluids. Also, higher levels of superoxide dismutase 2 and peroxiredoxin 2, but not superoxide dismutase 1, catalase and glutathione perioxidase 1, were consistently detected in the hip capsules of Group C patients. We propose that dysregulated reactive oxygen species-related enzymes may play an important role in the pathogenesis and progression of aseptic loosening after THR.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1302/0301-620X.93B9.26736 | DOI Listing |
J Arthroplasty
January 2025
Georgetown University School of Medicine, MedStar Georgetown University Hospital, Washington, D.C, USA. Electronic address:
Introduction: As the number of revision total knee arthroplasties (rTKA) continues to rise, there is increasing interest in the use of contemporary rotating hinge prostheses. These devices often incorporate porous cones to fill bone defects and enhance long-term fixation. This study evaluated the clinical and functional outcomes and survivorship in rTKA patients utilizing a rotating hinge prosthesis with flexible titanium (FT) cones, porous tantalum (PT) cones, or no cones.
View Article and Find Full Text PDFJ Clin Med
January 2025
Shoulder and Elbow Surgery, Schulthess Clinic Zürich, 8008 Zürich, Switzerland.
: Classical reverse shoulder arthroplasty (RSA) with a high neck-shaft angle (NSA) of 155° has shown satisfactory outcomes. However, newer RSA designs aim to improve results by modifying the stem design. This study evaluates the 5-year outcomes of a stem design featuring a rectangular metadiaphyseal fixation and a 135° NSA.
View Article and Find Full Text PDFDespite an increasing number of studies examining the effect of Single-Photon Emission Computed Tomography/ Computed Tomography (SPECT/CT) on improvement of diagnosis of aseptic loosening, there is still a great deal of uncertainty regarding its applicability in diagnostic algorithm. Therefore, in this meta-analysis, we aimed to investigate the diagnostic performance of SPECT/CT for identification of aseptic loosening in patients with persistent pain following the total knee arthroplasty (TKA) and total hip arthroplasty (THA). Electronic databases including Medline, Scopus, Web of Science, Cochrane library, and Embase were systematically searched for identifying relevant published studies from their inception to April 2023.
View Article and Find Full Text PDFZhongguo Gu Shang
January 2025
Department of Orthopaedics, Xuzhou Central Hospital, Xuzhou 221009, Jiangsu, China.
Objective: To investigate the clinical utility of novel of new hematological markers in the preoperative diagnosis of periprosthetic joint infection (PJI).
Methods: A retrospective analysis was conducted on a total of 149 patients who underwent revision of total hip arthroplasty (THA) or total knee arthroplasty (TKA) at a single center between January 2016 and June 2022, including 63 males and 86 females, aged from 47 to 93 years old with an average of (69.5±11.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
January 2025
Department of Artificial Joint Revision, Luoyang Orthopedic-Traumatological Hospital of Henan Province (Henan Provincial Orthopedic Hospital), Zhengzhou Henan, 450003, P. R. China.
Objective: To analyze the short-term effectiveness and safety of personalized three-dimensional (3D) printed customized prostheses in severe Paprosky type Ⅲ acetabular bone defects.
Methods: A retrospective analysis was conducted on 8 patients with severe Paprosky type Ⅲ acetabular bone defects and met the selection criteria between January 2023 and June 2024. There were 3 males and 5 females, with an average age of 64.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!