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Tumor cell-based liquid biopsy using high-throughput microfluidic enrichment of entire leukapheresis product.
Nat Commun
January 2025
Center for Engineering in Medicine and Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Circulating Tumor Cells (CTCs) in blood encompass DNA, RNA, and protein biomarkers, but clinical utility is limited by their rarity. To enable tumor epitope-agnostic interrogation of large blood volumes, we developed a high-throughput microfluidic device, depleting hematopoietic cells through high-flow channels and force-amplifying magnetic lenses. Here, we apply this technology to analyze patient-derived leukapheresis products, interrogating a mean blood volume of 5.
View Article and Find Full Text PDFAssociation of Vitamin D and Prostate Health Status in Men: An Analytical Cross-Sectional Study.
Cureus
December 2024
General Medicine, Sri Ramaswamy Memorial Medical College Hospital and Research Centre, Sri Ramaswamy Memorial Institute of Science and Technology, Kattankulathur, IND.
Article Synopsis
- Benign prostatic hyperplasia (BPH) is the leading cause of lower urinary tract symptoms, and the study explores how vitamin D's anti-inflammatory properties might help alleviate these symptoms.
- The research involved men aged 45 to 80 with urinary issues, categorizing them based on their prostate-specific antigen (PSA) levels to assess the link between vitamin D levels and prostate health.
- Results indicated that PSA levels rise with age, particularly in men over 60, and a negative correlation between PSA and vitamin D levels was found in men aged 60 to 69.
Article Synopsis
- The study investigates the role of DNA methylation as a prognostic marker in prostate cancer through two cohorts with long-term follow-up data.
- Initial analysis of a small dataset showed that higher methylation levels were linked to lethal disease, which was confirmed in a larger cohort where 97% of samples tested positive for methylation.
- Although methylation levels correlated with certain survival outcomes, they did not provide additional prognostic value beyond existing clinical features, indicating the need for further research into their clinical applications.
Silencing of STEAP3 suppresses cervical cancer cell proliferation and migration via JAK/STAT3 signaling pathway.
Cancer Metab
December 2024
Department of Obstetrics and Gynecology, First Affiliated Hospital, Shihezi University, Shihezi, China.
Article Synopsis
- STEAP3 is a critical protein associated with cervical cancer (CC) progression, showing strong expression in CC tissues and linked to poor patient prognosis.
- The study employed various methods, such as immunohistochemistry and RNA sequencing, to investigate STEAP3's role, revealing that lower methylation levels of STEAP3 are connected to worse outcomes.
- Knockdown of STEAP3 in CC cells reduced their growth and invasion abilities while enhancing drug sensitivity, suggesting STEAP3 drives cancer cell activity through the activation of the JAK/STAT3 signaling pathway.
Effect of repeated semen ejaculation on sperm quality and selected biochemical markers of canine semen.
Pol J Vet Sci
June 2024
Department of Animal Biochemistry and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5, 10-718 Olsztyn-Kortowo, Poland.
The aim of this study was to evaluate the quality parameters and selected biochemical markers of canine semen sampled at 24-h intervals over a period of 5 days, preceded by 6 months of sexual abstinence. Full ejaculates were obtained from 6 dogs. Ejaculate volume and total sperm counts in the ejaculate decreased gradually on successive sampling days.
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