AI Article Synopsis
- * Researchers used bone marrow-derived cells and implanted tissue-engineered constructs into muscle, observing bone formation through imaging and histological analysis.
- * Results showed that the group treated with EPCs had significantly higher bone mineral density and more extensive bone formation compared to the control group, indicating EPCs promote faster bone healing.
Article Abstract
Purpose: To observe the effects of endothelial progenitor cells (EPCs) on bone formation of tissue engineered bone in dogs.
Methods: Bone marrow stromal cells (BMSCs) and EPCs were derived from dog bone marrow and cultured in different medium in vitro. They were seeded on demineralized bone matrix (DBM) to build tissue engineered bone, then the construct was implanted into the fasciae of latissimus dorsi muscle, the degree of bone formation was analyzed with imaging and histological methods at different time points. SPSS13.0 software package was used for statistical analysis.
Results: 4, 8, 12 weeks after operation, X-ray film showed bone mineral density (BMD) in the EPCs group was significantly higher than the control group, and there was significant difference between the two groups(P<0.05); Histological examination revealed that the degree of bone formation in the EPCs group was higher than the control group, the new bone area and blood vessel area between the two groups were significantly different(P<0.05).
Conclusion: EPCs can promote bone formation and accelerate new bone formation in tissue-engineering bone.
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